N-{5-[8-(3-chloro-phenyl)-2-methyl-imidazo[1,2-a]pyridin-6-ylmethyl]-pyridin-2-yl}-2-dimethylamino-acetamide

Base Information

Chemical Name:N-{5-[8-(3-chloro-phenyl)-2-methyl-imidazo[1,2-a]pyridin-6-ylmethyl]-pyridin-2-yl}-2-dimethylamino-acetamide
CAS No.:1227243-16-4
Molecular Formula:C₂₄H₂₄ClN₅O
Molecular Weight:433.94
Hs Code.:

Synonyms:N-{5-[8-(3-chloro-phenyl)-2-methyl-imidazo[1,2-a]pyridin-6-ylmethyl]-pyridin-2-yl}-2-dimethylamino-acetamide

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Chemical Property of N-{5-[8-(3-chloro-phenyl)-2-methyl-imidazo[1,2-a]pyridin-6-ylmethyl]-pyridin-2-yl}-2-dimethylamino-acetamide

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Technology Process of N-{5-[8-(3-chloro-phenyl)-2-methyl-imidazo[1,2-a]pyridin-6-ylmethyl]-pyridin-2-yl}-2-dimethylamino-acetamide

There total 7 articles about N-{5-[8-(3-chloro-phenyl)-2-methyl-imidazo[1,2-a]pyridin-6-ylmethyl]-pyridin-2-yl}-2-dimethylamino-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1227243-07-3
5-[8-(3-chloro-phenyl)-2-methyl-imidazo[1,2-a]pyridin-6-ylmethyl]-pyridin-2-ylamine

: 60853-81-8
N,N-dimethylaminoacetyl chloride hydrochloride

: 1227243-16-4
N-{5-[8-(3-chloro-phenyl)-2-methyl-imidazo[1,2-a]pyridin-6-ylmethyl]-pyridin-2-yl}-2-dimethylamino-acetamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 40 ℃; for 72h;

Reference yield: 53.0%

: 5-[8-(3-chloro-phenyl)-2-methyl-imidazo[1,2-a]pyridin-6-ylmethyl]-pyridin-2-ylamine hydrochloride

: 60853-81-8
N,N-dimethylaminoacetyl chloride hydrochloride

: 1227243-16-4
N-{5-[8-(3-chloro-phenyl)-2-methyl-imidazo[1,2-a]pyridin-6-ylmethyl]-pyridin-2-yl}-2-dimethylamino-acetamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 40 ℃; for 72h;

Reference yield:

: 180340-70-9
methyl 6-amino-5-bromopyridine-3-carboxylate

: 1227243-16-4
N-{5-[8-(3-chloro-phenyl)-2-methyl-imidazo[1,2-a]pyridin-6-ylmethyl]-pyridin-2-yl}-2-dimethylamino-acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 6 h / 100 °C / Inert atmosphere

2.1: 3 h / 160 °C / Microwave irradiation

3.1: diisobutylaluminium hydride / tetrahydrofuran; hexane / -78 - 20 °C / Inert atmosphere

3.2: 0.33 h / 20 °C / Cooling with ice; Acidic aqueous solution

3.3: pH 8 - 9

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / -10 - 20 °C

4.2: 20 °C / Inert atmosphere

5.1: potassium carbonate / bis(η3-allyl-μ-chloropalladium(II)); 1,5-bis-(diphenylphosphino)pentane / N,N-dimethyl-formamide / 2 h / 90 °C

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 72 h / 40 °C

With sodium hydride; diisobutylaluminium hydride; sodium carbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(η3-allyl-μ-chloropalladium(II)); 1,5-bis-(diphenylphosphino)pentane; In tetrahydrofuran; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene; mineral oil;