(S)-(-)-N-(3,3-Diethoxypropyl)-3-(3,4-dimethoxyphenyl)-2-hydroxypropionamide

Base Information

• Chemical Name: (S)-(-)-N-(3,3-Diethoxypropyl)-3-(3,4-dimethoxyphenyl)-2-hydroxypropionamide
• CAS No.: 153309-68-3
• Molecular Formula: C₁₈H₂₉NO₆
• Molecular Weight: 355.431
• Mol file: 153309-68-3.mol

Synonyms:(S)-(-)-N-(3,3-Diethoxypropyl)-3-(3,4-dimethoxyphenyl)-2-hydroxypropionamide

Chemical Property of (S)-(-)-N-(3,3-Diethoxypropyl)-3-(3,4-dimethoxyphenyl)-2-hydroxypropionamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-(-)-N-(3,3-Diethoxypropyl)-3-(3,4-dimethoxyphenyl)-2-hydroxypropionamide

There total 3 articles about (S)-(-)-N-(3,3-Diethoxypropyl)-3-(3,4-dimethoxyphenyl)-2-hydroxypropionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

aminopropane diethyl acetal (41365-75-7) + Methyl (S)-(+)-3-(3,4 dimethoxyphenyl)-2-hydroxypropionate (153381-08-9) → (S)-(-)-N-(3,3-Diethoxypropyl)-3-(3,4-dimethoxyphenyl)-2-hydroxypropionamide (153309-68-3)

Guidance literature:

With toluene-4-sulfonic acid; at 140 ℃; for 2h;

DOI:10.1016/S0957-4166(00)80089-0 DOI:10.1002/ardp.19953280604

Reference yield:

3,3-bis(ethyloxy)propanenitrile (2032-34-0) → (S)-(-)-N-(3,3-Diethoxypropyl)-3-(3,4-dimethoxyphenyl)-2-hydroxypropionamide (153309-68-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 49 percent / LiAlH₄ / diethyl ether / 16 h / Ambient temperature

2: 97 percent / p-TsOH / 2 h / 140 °C

With lithium aluminium tetrahydride; toluene-4-sulfonic acid; In diethyl ether;

DOI:10.1002/ardp.19953280604

Reference yield:

3,3-bis(ethyloxy)propanenitrile (2032-34-0) → (S)-(-)-N-(3,3-Diethoxypropyl)-3-(3,4-dimethoxyphenyl)-2-hydroxypropionamide (153309-68-3)

Guidance literature:

Multi-step reaction with 2 steps

1: LiAlH₄

2: 97 percent / p-TsOH / 2 h / 140 °C

With lithium aluminium tetrahydride; toluene-4-sulfonic acid;

DOI:10.1016/S0957-4166(00)80089-0

upstream raw materials:

aminopropane diethyl acetal

Methyl (S)-(+)-3-(3,4 dimethoxyphenyl)-2-hydroxypropionate

3,3-bis(ethyloxy)propanenitrile