1-AMINO-3,3-DIETHOXYPROPANE

Base Information

• Chemical Name: 1-AMINO-3,3-DIETHOXYPROPANE
• CAS No.: 41365-75-7
• Molecular Formula: C7H17NO2
• Molecular Weight: 147.217
• Hs Code.: 2922199090
• Mol file: 41365-75-7.mol

Synonyms:3,3-Diethoxy-1-propanamine;3,3-Diethoxypropylamine;3-AMINOPROPIONALDEHYDE DIETHYL ACETAL;3,3-DIETHOXY-1-PROPYLAMINE;1-AMINO-3,3-DIETHOXYPROPANE;APEA;RARECHEM AL BW 0123;TIMTEC-BB SBB005781

Chemical Property of 1-AMINO-3,3-DIETHOXYPROPANE

Chemical Property:

• Appearance/Colour: clear colourless to yellow liquid
• Vapor Pressure: 0.321mmHg at 25°C
• Refractive Index: 1.4233-1.4253
• Boiling Point: 200.6 °C at 760 mmHg
• PKA: 8.92±0.13(Predicted)
• Flash Point: 79.3 °C
• PSA: 44.48000
• Density: 0.915 g/cm³
• LogP: 1.43460
• Storage Temp.: room temp
• Sensitive.: Air Sensitive

Purity/Quality:

97% ^*data from raw suppliers

1-?Amino-?3,?3-?Diethoxypropane ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-27-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-Amino-3,3-diethoxypropane has been used:with alginate in the preparation of hydrogelin the generation of polyethylene glycol (PEG) polyethylenimine (PEI) polyplexes conjugate for transfection studies in hepatocellular carcinoma cell culturesas a component of pH-sensitive PEG derivative for lipopolyplexes formation

Technology Process of 1-AMINO-3,3-DIETHOXYPROPANE

There total 11 articles about 1-AMINO-3,3-DIETHOXYPROPANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3-nitropropanal diethyl acetal (107833-73-8) → aminopropane diethyl acetal (41365-75-7)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 12h; under 7600.51 Torr;

DOI:10.1016/j.tetasy.2012.12.009

Reference yield: 87.0%

N-(3,3-diethoxypropyl)phthalimide (2453-90-9) → aminopropane diethyl acetal (41365-75-7)

Guidance literature:

With hydrazine; In methanol; for 2h; Heating;

DOI:10.1002/jhet.5570180519

Reference yield: 49.0%

3,3-bis(ethyloxy)propanenitrile (2032-34-0) → aminopropane diethyl acetal (41365-75-7)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 16h; Ambient temperature;

DOI:10.1002/ardp.19953280604

upstream raw materials:

3-chloro-1,1-diethoxy-propane

3,3-diethoxypropionic amide

N-(3,3-diethoxypropyl)phthalimide

3,3-bis(ethyloxy)propanenitrile

Downstream raw materials:

N-(3,3-diethoxypropyl)acetamide

1-(3,3-diethoxypropyl)-2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-1H-pyrrole

2-[1-(3,3-Diethoxy-propyl)-2-(4-fluoro-phenyl)-5-isopropyl-1H-pyrrol-3-yl]-pyridine

4-[1-(3,3-Diethoxy-propyl)-2-(4-fluoro-phenyl)-5-isopropyl-1H-pyrrol-3-yl]-pyridine

Refernces

N-GLYCOSIDES. V. 3-GLYCOSYL-4-HYDROXYHEXAHYDROPYRIMIDINE-2-THIONES AND THEIR ACYCLIC GLYCOSYLTHIOUREA PRECURSORS AS STIMULATORS OF NON-SPECIFIC RESISTANCE TO INFECTION

10.1007/BF01148382

The research focused on investigating the immuno-stimulating properties of certain glycosylthiourea and 3-glycosyl-4-hydroxyhexahydropyrimidine-2-thiones as stimulators of non-specific resistance to infection. The purpose was to understand the action of these compounds on natural immunity, particularly on the resistance of an organism to infection. The study utilized a series of compounds, including 3[B-D-gluco(galacto)-pyranosyl]-4-hydroxyhexahydropyrimidine-2-thiones (I and II), N'-[B-D-gluco(galacto)pyranosyl]-N3-(2-methyl-4-oxopentyl-2)thiourea (III and IV), and N'-[B-D-gluco(galacto)-pyranosyl]-NS-(3,3-diethoxypropyl)thiourea (V and VI), along with their aglycones. The synthesis involved chemicals such as 2,3,5-tri-O-acetyl-8-D-ribofuranosylisothiocyanate (VIII), 4-amino-4-methyl-2-pentanone (IX), and 3,3-diethoxypropylamine (X). The conclusions drawn from the biological experiments indicated that all test compounds demonstrated some level of stimulating action, with an index of resistance ranging from 2 to 6, and were comparable to known immunostimulators like taftsin, rigin, and levamisole. The effectiveness of these compounds was associated with an increase in proliferating processes in lymphoid and hematopoietic tissues, as evidenced by an increase in the number of stem cells in the spleens of lethally irradiated mice that received the test compounds.