5-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)-2-fluorobenzaldehyde

Base Information

Chemical Name:5-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)-2-fluorobenzaldehyde
CAS No.:1000998-64-0
Molecular Formula:C₁₈H₁₃ClFNO₃
Molecular Weight:345.758
Hs Code.:

Synonyms:5-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)-2-fluorobenzaldehyde

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Chemical Property of 5-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)-2-fluorobenzaldehyde

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Technology Process of 5-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)-2-fluorobenzaldehyde

There total 2 articles about 5-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)-2-fluorobenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 103438-84-2
methyl 2-amino-3-(2-fluoro-5-hydroxyphenyl)propanoate

: 832076-92-3
4-(chloromethyl)-2-(4-chlorophenyl)-5-methyl-1,3-oxazole

: 1000998-64-0
5-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)-2-fluorobenzaldehyde

Guidance literature:: With potassium carbonate; In acetonitrile; at 80 ℃; for 6h;

Reference yield:

: 105728-90-3
2-fluoro-5-methoxybenzaldehyde

: 1000998-64-0
5-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)-2-fluorobenzaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: boron tribromide / dichloromethane / -78 - 0 °C

2: potassium carbonate / acetonitrile / 6 h / 80 °C / Inert atmosphere

With boron tribromide; potassium carbonate; In dichloromethane; acetonitrile;
DOI:10.1021/acsmedchemlett.6b00033

Reference yield: 72.0%

: 1000998-64-0
5-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)-2-fluorobenzaldehyde

: 5680-79-5,883886-67-7
glycine ethyl ester hydrochloride

: 1000998-66-2
methyl 2-(5-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)-2-fluorobenzylamino)acetate

Guidance literature:: 5-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)-2-fluorobenzaldehyde; glycine ethyl ester hydrochloride; With triethylamine; In methanol; at 20 ℃; Inert atmosphere;

With sodium tetrahydroborate; In methanol; at -5 - 20 ℃; for 1h; Inert atmosphere;
DOI:10.1021/acsmedchemlett.6b00033