1-benzyl-N-{[1-(4-fluorophenyl)cyclopentyl]methyl}piperidine-4-carboxamide hydrochloride

Base Information

Chemical Name:1-benzyl-N-{[1-(4-fluorophenyl)cyclopentyl]methyl}piperidine-4-carboxamide hydrochloride
CAS No.:1338349-08-8
Molecular Formula:C₂₅H₃₁FN₂O*ClH
Molecular Weight:430.993
Hs Code.:

Synonyms:1-benzyl-N-{[1-(4-fluorophenyl)cyclopentyl]methyl}piperidine-4-carboxamide hydrochloride

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Chemical Property of 1-benzyl-N-{[1-(4-fluorophenyl)cyclopentyl]methyl}piperidine-4-carboxamide hydrochloride

Chemical Property:

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Technology Process of 1-benzyl-N-{[1-(4-fluorophenyl)cyclopentyl]methyl}piperidine-4-carboxamide hydrochloride

There total 5 articles about 1-benzyl-N-{[1-(4-fluorophenyl)cyclopentyl]methyl}piperidine-4-carboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₈H₂₅FN₂O*ClH

: 100-52-7
benzaldehyde

: 1338349-08-8
1-benzyl-N-{[1-(4-fluorophenyl)cyclopentyl]methyl}piperidine-4-carboxamide hydrochloride

Guidance literature:: C₁₈H₂₅FN₂O*ClH; benzaldehyde; With sodium acetate; sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 15h;

With hydrogenchloride; In ethyl acetate;
DOI:10.1016/j.bmc.2011.07.030

Reference yield:

: 1338349-00-0
tert-butyl 4-({[1-(4-fluorophenyl)cyclopentyl]methyl}carbamoyl)piperidine-1-carboxylate

: 1338349-08-8
1-benzyl-N-{[1-(4-fluorophenyl)cyclopentyl]methyl}piperidine-4-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / ethyl acetate / 18 h / 20 °C / Cooling with ice

2: sodium acetate; sodium tris(acetoxy)borohydride / dichloromethane / 15 h / 20 °C

With hydrogenchloride; sodium acetate; sodium tris(acetoxy)borohydride; In dichloromethane; ethyl acetate;
DOI:10.1016/j.bmc.2011.07.030

Reference yield:

: 75180-50-6
(1-(4-fluorophenyl)cyclopentyl)methanamine

: 1338349-08-8
1-benzyl-N-{[1-(4-fluorophenyl)cyclopentyl]methyl}piperidine-4-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 26 h / 20 °C

2: hydrogenchloride / ethyl acetate / 18 h / 20 °C / Cooling with ice

3: sodium acetate; sodium tris(acetoxy)borohydride / dichloromethane / 15 h / 20 °C

With hydrogenchloride; sodium acetate; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.07.030