(2S)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-benzyl-2-cyanobutanoate

Base Information

Chemical Name:(2S)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-benzyl-2-cyanobutanoate
CAS No.:154520-15-7
Molecular Formula:C₃₄H₅₀N₂O₄S
Molecular Weight:582.848
Hs Code.:

Synonyms:(2S)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-benzyl-2-cyanobutanoate

Suppliers and Price of (2S)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-benzyl-2-cyanobutanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-benzyl-2-cyanobutanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-benzyl-2-cyanobutanoate

There total 3 articles about (2S)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-benzyl-2-cyanobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 620-05-3
iodomethylbenzene

: 610784-26-4
(2RS)-(1'S,2'R,4'R)-10'-(dicyclohexylsulfamoyl)isobornyl-2-cyanobutanoate

: 154520-15-7
(2S)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-benzyl-2-cyanobutanoate

: (2R)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-benzyl-2-cyanobutanoate

Guidance literature:: With lithium diisopropyl amide; Yields of byproduct given; 1.) THF, -78 deg C, 1 h, 2.) THF, HMPA, -78 deg C to r.t.; r.t., 1 d;
DOI:10.1021/jo00088a034

Reference yield:

: 51789-75-4
1-cyano-propane-1-carboxylic acid

: 154520-15-7
(2S)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-benzyl-2-cyanobutanoate

Guidance literature:: Multi-step reaction with 3 steps

1: PCl₅

2: 91 percent / AgCN / toluene / 4 h / 80 °C

3: 68 percent / LDA / 1.) THF, -78 deg C, 1 h, 2.) THF, HMPA, -78 deg C to r.t.; r.t., 1 d

With silver cyanide; phosphorus pentachloride; lithium diisopropyl amide; In toluene;
DOI:10.1021/jo00088a034

Reference yield:

: 57244-09-4
2-Cyanobutanoyl chloride

: 154520-15-7
(2S)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-benzyl-2-cyanobutanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / AgCN / toluene / 4 h / 80 °C

2: 68 percent / LDA / 1.) THF, -78 deg C, 1 h, 2.) THF, HMPA, -78 deg C to r.t.; r.t., 1 d

With silver cyanide; lithium diisopropyl amide; In toluene;
DOI:10.1021/jo00088a034