(2S)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-(aminomethyl)-2-benzylbutanoate

Base Information

Chemical Name:(2S)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-(aminomethyl)-2-benzylbutanoate
CAS No.:154520-25-9
Molecular Formula:C₃₄H₅₄N₂O₄S
Molecular Weight:586.88
Hs Code.:

Synonyms:(2S)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-(aminomethyl)-2-benzylbutanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-(aminomethyl)-2-benzylbutanoate

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Technology Process of (2S)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-(aminomethyl)-2-benzylbutanoate

There total 4 articles about (2S)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-(aminomethyl)-2-benzylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 154520-15-7
(2S)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-benzyl-2-cyanobutanoate

: 154520-25-9
(2S)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-(aminomethyl)-2-benzylbutanoate

Guidance literature:: With hydrogen; rhodium on alumina; In ethanol; ammonia; at 35 ℃; for 24h;
DOI:10.1021/jo00088a034

Reference yield:

: 51789-75-4
1-cyano-propane-1-carboxylic acid

: 154520-25-9
(2S)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-(aminomethyl)-2-benzylbutanoate

Guidance literature:: Multi-step reaction with 4 steps

1: PCl₅

2: 91 percent / AgCN / toluene / 4 h / 80 °C

3: 68 percent / LDA / 1.) THF, -78 deg C, 1 h, 2.) THF, HMPA, -78 deg C to r.t.; r.t., 1 d

4: 83 percent / H₂ / 5percent Rh-Al₂O₃ / ethanol; NH₃ / 24 h / 35 °C

With silver cyanide; phosphorus pentachloride; hydrogen; lithium diisopropyl amide; rhodium on alumina; In ethanol; ammonia; toluene;
DOI:10.1021/jo00088a034

Reference yield:

: 610784-26-4
(2RS)-(1'S,2'R,4'R)-10'-(dicyclohexylsulfamoyl)isobornyl-2-cyanobutanoate

: 154520-25-9
(2S)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-(aminomethyl)-2-benzylbutanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 68 percent / LDA / 1.) THF, -78 deg C, 1 h, 2.) THF, HMPA, -78 deg C to r.t.; r.t., 1 d

2: 83 percent / H₂ / 5percent Rh-Al₂O₃ / ethanol; NH₃ / 24 h / 35 °C

With hydrogen; lithium diisopropyl amide; rhodium on alumina; In ethanol; ammonia;
DOI:10.1021/jo00088a034