1-[2-[3-(2-amino-ethyl)-1H-indol-5-yloxy]-acetyl]-4-[o-tolyl]-piperazide

Base Information

Chemical Name:1-[2-[3-(2-amino-ethyl)-1H-indol-5-yloxy]-acetyl]-4-[o-tolyl]-piperazide
CAS No.:157694-57-0
Molecular Formula:C₂₃H₂₈N₄O₂
Molecular Weight:392.501
Hs Code.:

Synonyms:1-[2-[3-(2-amino-ethyl)-1H-indol-5-yloxy]-acetyl]-4-[o-tolyl]-piperazide

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Chemical Property of 1-[2-[3-(2-amino-ethyl)-1H-indol-5-yloxy]-acetyl]-4-[o-tolyl]-piperazide

Chemical Property:

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Technology Process of 1-[2-[3-(2-amino-ethyl)-1H-indol-5-yloxy]-acetyl]-4-[o-tolyl]-piperazide

There total 4 articles about 1-[2-[3-(2-amino-ethyl)-1H-indol-5-yloxy]-acetyl]-4-[o-tolyl]-piperazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 157694-81-0
(2-{5-[2-Oxo-2-(4-o-tolyl-piperazin-1-yl)-ethoxy]-1H-indol-3-yl}-ethyl)-carbamic acid tert-butyl ester

: 157694-57-0
1-[2-[3-(2-amino-ethyl)-1H-indol-5-yloxy]-acetyl]-4-[o-tolyl]-piperazide

Guidance literature:: With trifluoroacetic acid; In toluene; at 25 ℃; for 1h;
DOI:10.1021/jm00018a020

Reference yield:

: 39512-51-1
1-(o-toluyl)piperazine

: 157694-57-0
1-[2-[3-(2-amino-ethyl)-1H-indol-5-yloxy]-acetyl]-4-[o-tolyl]-piperazide

Guidance literature:: Multi-step reaction with 3 steps

1: CaCO₃ / butan-2-one / Ambient temperature

2: K₂CO₃, KI / butan-2-one / 16 h / Heating

3: TFA / toluene / 1 h / 25 °C

With potassium carbonate; trifluoroacetic acid; calcium carbonate; potassium iodide; In toluene; butanone;
DOI:10.1021/jm00018a020

Reference yield:

: 53157-48-5
tert-butyl 2-(5-hydroxy-1H-indol-3-yl)ethylcarbamate

: 157694-57-0
1-[2-[3-(2-amino-ethyl)-1H-indol-5-yloxy]-acetyl]-4-[o-tolyl]-piperazide

Guidance literature:: Multi-step reaction with 2 steps

1: K₂CO₃, KI / butan-2-one / 16 h / Heating

2: TFA / toluene / 1 h / 25 °C

With potassium carbonate; trifluoroacetic acid; potassium iodide; In toluene; butanone;
DOI:10.1021/jm00018a020