4-{4-[4-(1,1-dioxo-tetrahydro-1λ6-thiophen-3-ylmethoxy)-indol-1-yl]-pyrimidin-2-ylamino}-cyclohexanecarboxylic acid ethyl ester

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Chemical Name:4-{4-[4-(1,1-dioxo-tetrahydro-1λ6-thiophen-3-ylmethoxy)-indol-1-yl]-pyrimidin-2-ylamino}-cyclohexanecarboxylic acid ethyl ester
CAS No.:1351990-45-8
Molecular Formula:C₂₆H₃₂N₄O₅S
Molecular Weight:512.63
Hs Code.:

Synonyms:4-{4-[4-(1,1-dioxo-tetrahydro-1λ6-thiophen-3-ylmethoxy)-indol-1-yl]-pyrimidin-2-ylamino}-cyclohexanecarboxylic acid ethyl ester

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Chemical Property of 4-{4-[4-(1,1-dioxo-tetrahydro-1λ6-thiophen-3-ylmethoxy)-indol-1-yl]-pyrimidin-2-ylamino}-cyclohexanecarboxylic acid ethyl ester

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Technology Process of 4-{4-[4-(1,1-dioxo-tetrahydro-1λ6-thiophen-3-ylmethoxy)-indol-1-yl]-pyrimidin-2-ylamino}-cyclohexanecarboxylic acid ethyl ester

There total 4 articles about 4-{4-[4-(1,1-dioxo-tetrahydro-1λ6-thiophen-3-ylmethoxy)-indol-1-yl]-pyrimidin-2-ylamino}-cyclohexanecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1351990-44-7
4-(1,1-dioxo-tetrahydro-1λ6-thiophen-3-ylmethoxy)-1-[2-(propane-1-sulfinyl)-pyrimidin-4-yl]-1H-indole

: 2084-28-8,61367-17-7
trans-4-aminocyclohexanecarboxylic acid ethyl ester hydrochloride

: 1351990-45-8
4-{4-[4-(1,1-dioxo-tetrahydro-1λ6-thiophen-3-ylmethoxy)-indol-1-yl]-pyrimidin-2-ylamino}-cyclohexanecarboxylic acid ethyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 80 ℃; for 18h;

Reference yield:

: 4785-67-5
1,1-dioxo-tetrahydro-1λ⁶-thiophene-3-carboxylic acid

: 1351990-45-8
4-{4-[4-(1,1-dioxo-tetrahydro-1λ6-thiophen-3-ylmethoxy)-indol-1-yl]-pyrimidin-2-ylamino}-cyclohexanecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 5 h / 20 °C

1.2: 60 h / 20 °C

2.1: pyridine / chloroform / 60 °C

3.1: caesium carbonate / 1-methyl-pyrrolidin-2-one / 60 h / 70 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.75 h / 0 °C

5.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 18 h / 80 °C

With pyridine; lithium aluminium tetrahydride; caesium carbonate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; chloroform;

Reference yield:

: 17236-20-3
3-(hydroxymethyl)tetrahydrothiophene 1,1-dioxide

: 1351990-45-8
4-{4-[4-(1,1-dioxo-tetrahydro-1λ6-thiophen-3-ylmethoxy)-indol-1-yl]-pyrimidin-2-ylamino}-cyclohexanecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / chloroform / 60 °C

2: caesium carbonate / 1-methyl-pyrrolidin-2-one / 60 h / 70 °C

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.75 h / 0 °C

4: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 18 h / 80 °C

With pyridine; caesium carbonate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In 1-methyl-pyrrolidin-2-one; dichloromethane; chloroform;