2-cyanoethyl <8-(4,4'-dimethoxytrityloxy)-3,6-bis(2,4-dinitrophenyl)-3,6-diazaoctyl> N,N-di-isopropylphosphoramidite

Base Information

Chemical Name:2-cyanoethyl <8-(4,4'-dimethoxytrityloxy)-3,6-bis(2,4-dinitrophenyl)-3,6-diazaoctyl> N,N-di-isopropylphosphoramidite
CAS No.:136949-88-7
Molecular Formula:C₄₈H₅₅N₈O₁₃P
Molecular Weight:982.984
Hs Code.:

Synonyms:2-cyanoethyl <8-(4,4'-dimethoxytrityloxy)-3,6-bis(2,4-dinitrophenyl)-3,6-diazaoctyl> N,N-di-isopropylphosphoramidite

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Chemical Property of 2-cyanoethyl <8-(4,4'-dimethoxytrityloxy)-3,6-bis(2,4-dinitrophenyl)-3,6-diazaoctyl> N,N-di-isopropylphosphoramidite

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Technology Process of 2-cyanoethyl <8-(4,4'-dimethoxytrityloxy)-3,6-bis(2,4-dinitrophenyl)-3,6-diazaoctyl> N,N-di-isopropylphosphoramidite

There total 4 articles about 2-cyanoethyl <8-(4,4'-dimethoxytrityloxy)-3,6-bis(2,4-dinitrophenyl)-3,6-diazaoctyl> N,N-di-isopropylphosphoramidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 136949-87-6
8-(4,4'-dimethoxytrityloxy)-3,6-bis(2,4-dinitrophenyl)-3,6-diazaoctan-1-ol

: 136949-88-7
2-cyanoethyl <8-(4,4'-dimethoxytrityloxy)-3,6-bis(2,4-dinitrophenyl)-3,6-diazaoctyl> N,N-di-isopropylphosphoramidite

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 0.25h;
DOI:10.1016/0008-6215(92)84170-W

Reference yield:

: 4439-20-7
N,N'-bis(2-hydroxyethyl)ethylene diamine

: 136949-88-7
2-cyanoethyl <8-(4,4'-dimethoxytrityloxy)-3,6-bis(2,4-dinitrophenyl)-3,6-diazaoctyl> N,N-di-isopropylphosphoramidite

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / Et₃N / methanol / 3.5 h

2: 31 percent / pyridine / a) 2 h, b) 30 min

3: 84 percent / N,N-di-isopropylethylamine / tetrahydrofuran / 0.25 h / 20 °C

With pyridine; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol;
DOI:10.1016/0008-6215(92)84170-W

Reference yield:

: 70-34-8,65727-75-5
2,4-Dinitrofluorobenzene

: 136949-88-7
2-cyanoethyl <8-(4,4'-dimethoxytrityloxy)-3,6-bis(2,4-dinitrophenyl)-3,6-diazaoctyl> N,N-di-isopropylphosphoramidite

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / Et₃N / methanol / 3.5 h

2: 31 percent / pyridine / a) 2 h, b) 30 min

3: 84 percent / N,N-di-isopropylethylamine / tetrahydrofuran / 0.25 h / 20 °C

With pyridine; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol;
DOI:10.1016/0008-6215(92)84170-W