2-(ethylsulfanyl)-3-[4-(2,2,2-trifluoroethoxy)phenyl]-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidine-4-one

Base Information

• Chemical Name: 2-(ethylsulfanyl)-3-[4-(2,2,2-trifluoroethoxy)phenyl]-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidine-4-one
• CAS No.: 1236766-57-6
• Molecular Formula: C₁₆H₁₄F₃N₃O₂S
• Molecular Weight: 369.367

Synonyms:2-(ethylsulfanyl)-3-[4-(2,2,2-trifluoroethoxy)phenyl]-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidine-4-one

Chemical Property of 2-(ethylsulfanyl)-3-[4-(2,2,2-trifluoroethoxy)phenyl]-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidine-4-one

Chemical Property:

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Technology Process of 2-(ethylsulfanyl)-3-[4-(2,2,2-trifluoroethoxy)phenyl]-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidine-4-one

There total 1 articles about 2-(ethylsulfanyl)-3-[4-(2,2,2-trifluoroethoxy)phenyl]-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidine-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-thioxo-3-[4-(2,2,2-trifluoroethoxy)phenyl]-1,2,3,7-tetrahydro-4H-pyrrolo[2,3-d]pyrimidin-4-one (1236764-86-5) + ethyl iodide (75-03-6) → 2-(ethylsulfanyl)-3-[4-(2,2,2-trifluoroethoxy)phenyl]-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidine-4-one (1236766-57-6)

Guidance literature:

With sodium hydrogencarbonate; In water; N,N-dimethyl-formamide; at 40 ℃; for 0.5h; Reflux;

Reference yield:

2-(ethylsulfanyl)-3-[4-(2,2,2-trifluoroethoxy)phenyl]-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidine-4-one (1236766-57-6) + cyclopropylcarbinyl bromide (7051-34-5) → 7-(cyclopropylmethyl)-2-(ethylsulfanyl)-3-[4-(2,2,2-trifluoroethoxy)phenyl]-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidine-4-one (1236766-66-7)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; Cooling with ice; Inert atmosphere;

Reference yield:

2-(ethylsulfanyl)-3-[4-(2,2,2-trifluoroethoxy)phenyl]-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidine-4-one (1236766-57-6) + chloromethyl methyl ether (107-30-2) → 2-(ethylsulfanyl)-7-(methoxymethyl)-3-[4-(2,2,2-trifluoroethoxy)phenyl]-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidine-4-one (1236766-67-8)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; Cooling with ice; Inert atmosphere;

upstream raw materials:

2-thioxo-3-[4-(2,2,2-trifluoroethoxy)phenyl]-1,2,3,7-tetrahydro-4H-pyrrolo[2,3-d]pyrimidin-4-one

ethyl iodide

Downstream raw materials:

7-(cyclopropylmethyl)-2-(ethylsulfanyl)-3-[4-(2,2,2-trifluoroethoxy)phenyl]-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidine-4-one

2-(ethylsulfanyl)-7-(methoxymethyl)-3-[4-(2,2,2-trifluoroethoxy)phenyl]-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidine-4-one

2-(ethylsulfanyl)-3-[4-(2,2,2-trifluoroethoxy)phenyl]-7-(2,2,2-trifluoroethyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidine-4-one

7-(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)-2-(ethylsulfanyl)-3-[4-(2,2,2-trifluoroethoxy)phenyl]-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidine-4-one

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