3-[4-(2-chloro-ethoxy)-3,5-dimethyl-phenyl]-6,8-dimethoxy-isochromen-1-one

Base Information

Chemical Name:3-[4-(2-chloro-ethoxy)-3,5-dimethyl-phenyl]-6,8-dimethoxy-isochromen-1-one
CAS No.:924300-56-1
Molecular Formula:C₂₁H₂₁ClO₅
Molecular Weight:388.848
Hs Code.:

Synonyms:3-[4-(2-chloro-ethoxy)-3,5-dimethyl-phenyl]-6,8-dimethoxy-isochromen-1-one

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Chemical Property of 3-[4-(2-chloro-ethoxy)-3,5-dimethyl-phenyl]-6,8-dimethoxy-isochromen-1-one

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Technology Process of 3-[4-(2-chloro-ethoxy)-3,5-dimethyl-phenyl]-6,8-dimethoxy-isochromen-1-one

There total 10 articles about 3-[4-(2-chloro-ethoxy)-3,5-dimethyl-phenyl]-6,8-dimethoxy-isochromen-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 924300-55-0
3-(4-hydroxy-3,5-dimethyl-phenyl)-6,8-dimethoxy-isochromen-1-one

: 624-70-4
1-chloro-2-iodoethane

: 924300-56-1
3-[4-(2-chloro-ethoxy)-3,5-dimethyl-phenyl]-6,8-dimethoxy-isochromen-1-one

Guidance literature:: 3-(4-hydroxy-3,5-dimethyl-phenyl)-6,8-dimethoxy-isochromen-1-one; With sodium hydride; In N,N-dimethyl-formamide; for 1h;

1-chloro-2-iodoethane; In N,N-dimethyl-formamide; at 80 ℃; for 16h;

With hydrogenchloride; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield: 35.0%

: 624-70-4
1-chloro-2-iodoethane

: 924300-56-1
3-[4-(2-chloro-ethoxy)-3,5-dimethyl-phenyl]-6,8-dimethoxy-isochromen-1-one

Guidance literature:: 3-(4-hydroxy-3,5-dimethyl-phenyl)-6,8-dimethoxy-isochromen-1-one; With sodium hydride; In N,N-dimethyl-formamide; for 1h;

1-chloro-2-iodoethane; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

: 4919-37-3
3,5-dimethyl-4-hydroxybenzoic acid

: 924300-56-1
3-[4-(2-chloro-ethoxy)-3,5-dimethyl-phenyl]-6,8-dimethoxy-isochromen-1-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / 4 h / 20 °C

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C / Inert atmosphere

3.1: triethylamine; N,N,N',N'-tetramethylguanidine / acetonitrile / 17 h / 0 - 20 °C / Reflux

3.2: 2 h / 100 °C

3.3: 6 h / 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h

4.2: 16 h / 80 °C

With pyridine; oxalyl dichloride; sodium hydride; triethylamine; N,N-dimethyl-formamide; N,N,N',N'-tetramethylguanidine; In dichloromethane; N,N-dimethyl-formamide; acetonitrile; mineral oil;