[(3R)-2-benzyl-3-(hydroxymethyl)-8-(trifluoromethyl)-2,3-di-hydro-1H-2-benzaze-pin-4-yl]methanol

Base Information

Chemical Name:[(3R)-2-benzyl-3-(hydroxymethyl)-8-(trifluoromethyl)-2,3-di-hydro-1H-2-benzaze-pin-4-yl]methanol
CAS No.:1365841-33-3
Molecular Formula:C₂₀H₂₀F₃NO₂
Molecular Weight:363.38
Hs Code.:

Synonyms:[(3R)-2-benzyl-3-(hydroxymethyl)-8-(trifluoromethyl)-2,3-di-hydro-1H-2-benzaze-pin-4-yl]methanol

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Chemical Property of [(3R)-2-benzyl-3-(hydroxymethyl)-8-(trifluoromethyl)-2,3-di-hydro-1H-2-benzaze-pin-4-yl]methanol

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Technology Process of [(3R)-2-benzyl-3-(hydroxymethyl)-8-(trifluoromethyl)-2,3-di-hydro-1H-2-benzaze-pin-4-yl]methanol

There total 10 articles about [(3R)-2-benzyl-3-(hydroxymethyl)-8-(trifluoromethyl)-2,3-di-hydro-1H-2-benzaze-pin-4-yl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1365841-23-1
(6R,7R)-8-benzyl-6-{[(1R,2S,5R)-5-methyl-2-(propan-2-yl)-cyclohexyl]oxy}-12-(trifluoromethyl)-5-oxa-8-azatricyclo-[8.4.0.0^3,7]tetradeca-1⁽¹⁴⁾,2,10,12-tetraen-4-one

: 1365841-33-3
[(3R)-2-benzyl-3-(hydroxymethyl)-8-(trifluoromethyl)-2,3-di-hydro-1H-2-benzaze-pin-4-yl]methanol

Guidance literature:: With diisobutylaluminium hydride; In tetrahydrofuran; toluene; at -78 ℃; for 7h;
DOI:10.1021/jo3001657

Reference yield:

: 1365840-90-9
tert-butyl N-benzyl-N-{[2-ethenyl-5-(trifluoromethyl)-phenyl]methyl}carbamate

: 1365841-33-3
[(3R)-2-benzyl-3-(hydroxymethyl)-8-(trifluoromethyl)-2,3-di-hydro-1H-2-benzaze-pin-4-yl]methanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: 2,6-dimethylpyridine / 1,1-dichloroethane / 4 h / 96 °C

2.1: osmium(VIII) oxide / tetrahydrofuran; water; toluene / 0.13 h

2.2: 1 h

3.1: n-butyllithium; diphenyl diselenide; lithium phenylselenide / tetrahydrofuran; hexane; acetonitrile / 8.17 h / -42 - -20 °C

4.1: pyridine; dmap / dichloromethane / 0.83 h / 0 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.17 h / 0 °C

6.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 7 h / -78 °C

With pyridine; 2,6-dimethylpyridine; dmap; osmium(VIII) oxide; n-butyllithium; diphenyl diselenide; lithium phenylselenide; tetrabutyl ammonium fluoride; diisobutylaluminium hydride; In tetrahydrofuran; 1,1-dichloroethane; hexane; dichloromethane; water; toluene; acetonitrile;
DOI:10.1021/jo3001657

Reference yield:

: 1365840-91-0
tris(propan-2-yl)silyl N-benzyl-N-{[2-ethenyl-5-(trifluoromethyl)phenyl]methyl}carbamate

: 1365841-33-3
[(3R)-2-benzyl-3-(hydroxymethyl)-8-(trifluoromethyl)-2,3-di-hydro-1H-2-benzaze-pin-4-yl]methanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: osmium(VIII) oxide / tetrahydrofuran; water; toluene / 0.13 h

1.2: 1 h

2.1: n-butyllithium; diphenyl diselenide; lithium phenylselenide / tetrahydrofuran; hexane; acetonitrile / 8.17 h / -42 - -20 °C

3.1: pyridine; dmap / dichloromethane / 0.83 h / 0 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.17 h / 0 °C

5.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 7 h / -78 °C

With pyridine; dmap; osmium(VIII) oxide; n-butyllithium; diphenyl diselenide; lithium phenylselenide; tetrabutyl ammonium fluoride; diisobutylaluminium hydride; In tetrahydrofuran; hexane; dichloromethane; water; toluene; acetonitrile;
DOI:10.1021/jo3001657