tert-butyl N-benzyl-N-{[2-ethenyl-5-(trifluoromethyl)-phenyl]methyl}carbamate

Base Information

Chemical Name:tert-butyl N-benzyl-N-{[2-ethenyl-5-(trifluoromethyl)-phenyl]methyl}carbamate
CAS No.:1365840-90-9
Molecular Formula:C₂₂H₂₄F₃NO₂
Molecular Weight:391.433
Hs Code.:

Synonyms:tert-butyl N-benzyl-N-{[2-ethenyl-5-(trifluoromethyl)-phenyl]methyl}carbamate

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Chemical Property of tert-butyl N-benzyl-N-{[2-ethenyl-5-(trifluoromethyl)-phenyl]methyl}carbamate

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Technology Process of tert-butyl N-benzyl-N-{[2-ethenyl-5-(trifluoromethyl)-phenyl]methyl}carbamate

There total 3 articles about tert-butyl N-benzyl-N-{[2-ethenyl-5-(trifluoromethyl)-phenyl]methyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1365840-89-6
tert-butyl N-{[2-ethenyl-5-(trifluoromethyl)phenyl]methyl}-carbamate

: 100-39-0
benzyl bromide

: 1365840-90-9
tert-butyl N-benzyl-N-{[2-ethenyl-5-(trifluoromethyl)-phenyl]methyl}carbamate

Guidance literature:: tert-butyl N-{[2-ethenyl-5-(trifluoromethyl)phenyl]methyl}-carbamate; With sodium hydride; In N,N-dimethyl-formamide; oil; for 0.5h;

benzyl bromide; In N,N-dimethyl-formamide; for 19.5h;
DOI:10.1021/jo3001657

Reference yield:

: 771582-26-4
(2-bromo-5-(trifluoromethyl)phenyl)methanamine

: 1365840-90-9
tert-butyl N-benzyl-N-{[2-ethenyl-5-(trifluoromethyl)-phenyl]methyl}carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dichloromethane / 14 h

2.1: palladium diacetate; triphenylphosphine / toluene / 19.08 h / 110 - 120 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide; oil / 0.5 h

3.2: 19.5 h

With palladium diacetate; sodium hydride; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide; toluene; oil;
DOI:10.1021/jo3001657

Reference yield:

: 1483-55-2
2-bromo-5-trifluoromethylbenzonitrile

: 1365840-90-9
tert-butyl N-benzyl-N-{[2-ethenyl-5-(trifluoromethyl)-phenyl]methyl}carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium tetrahydroborate; trifluoroacetic acid

2.1: dichloromethane / 14 h

3.1: palladium diacetate; triphenylphosphine / toluene / 19.08 h / 110 - 120 °C / Inert atmosphere

4.1: sodium hydride / N,N-dimethyl-formamide; oil / 0.5 h

4.2: 19.5 h

With sodium tetrahydroborate; palladium diacetate; sodium hydride; triphenylphosphine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; toluene; oil;
DOI:10.1021/jo3001657