2-BROMO-5-TRIFLUOROMETHYL-BENZYLAMINE

Base Information

• Chemical Name: 2-BROMO-5-TRIFLUOROMETHYL-BENZYLAMINE
• CAS No.: 771582-26-4
• Molecular Formula: C₈H₇BrF₃N
• Molecular Weight: 254.049
• Mol file: 771582-26-4.mol

Synonyms:(2-bromo-5-(trifluoromethyl)phenyl)methanamine

Chemical Property of 2-BROMO-5-TRIFLUOROMETHYL-BENZYLAMINE

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

2-Bromo-5-trifluoromethylbenzylamine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-BROMO-5-TRIFLUOROMETHYL-BENZYLAMINE

There total 4 articles about 2-BROMO-5-TRIFLUOROMETHYL-BENZYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-bromo-5-trifluoromethylbenzonitrile (1483-55-2) → (2-bromo-5-(trifluoromethyl)phenyl)methanamine (771582-26-4)

Guidance literature:

With sodium tetrahydroborate; trifluoroacetic acid; In tetrahydrofuran; at 20 ℃; for 16.5h; Cooling with ice;

Reference yield: 65.0%

2-bromo-5-(trifluoromethyl)benzaldehyde (102684-91-3) → (2-bromo-5-(trifluoromethyl)phenyl)methanamine (771582-26-4)

Guidance literature:

2-bromo-5-(trifluoromethyl)benzaldehyde; With hydroxylamine; In methanol; at 20 ℃; for 3h;

With acetic acid; zinc;

Reference yield: 60.0%

2-(2-bromo-5-(trifluoromethyl)benzyl)isoindoline-1,3-dione → (2-bromo-5-(trifluoromethyl)phenyl)methanamine (771582-26-4)

Guidance literature:

With hydrazine hydrate; In acetonitrile; for 22h; Reflux;

DOI:10.1021/ol4025259

upstream raw materials:

2-bromo-5-trifluoromethylbenzonitrile

2-bromo-5-(trifluoromethyl)benzaldehyde

p-trifluoromethylphenyl bromide

Downstream raw materials:

tert-butyl N-{[2-ethenyl-5-(trifluoromethyl)phenyl]methyl}-carbamate

tert-butyl N-benzyl-N-{[2-ethenyl-5-(trifluoromethyl)-phenyl]methyl}carbamate

tris(propan-2-yl)silyl N-benzyl-N-{[2-ethenyl-5-(trifluoromethyl)phenyl]methyl}carbamate

tris(propan-2-yl)silyl N-benzyl-N-{[2-formyl-5-(trifluoromethyl)phenyl]methyl}carbamate

Refernces

• 1、 -. "New CRTh2 antagonists.". Paragraph 0171. . Retrieved 2013/03/26.
• 2、 Mestichelli, Paola,Scott, Matthew J.,Galloway, Warren R. J. D.,Selwyn, Jamie,Parker, Jeremy S.,Spring, David R.. "Concise copper-catalyzed synthesis of tricyclic biaryl ether-linked aza-heterocyclic ring systems". . p. 5448 - 5451. Retrieved 2013/11/19.