(4Z)-7-Methyl-4-<(2RS,3RS)-3-hydroxy-4-methyl-2-p-toluenesulphonylethyliden-1-yl>-isochroman-1-one

Base Information

Chemical Name:(4Z)-7-Methyl-4-<(2RS,3RS)-3-hydroxy-4-methyl-2-p-toluenesulphonylethyliden-1-yl>-isochroman-1-one
CAS No.:130767-22-5
Molecular Formula:C₂₃H₂₆O₅S
Molecular Weight:414.522
Hs Code.:

Synonyms:(4Z)-7-Methyl-4-<(2RS,3RS)-3-hydroxy-4-methyl-2-p-toluenesulphonylethyliden-1-yl>-isochroman-1-one

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Chemical Property of (4Z)-7-Methyl-4-<(2RS,3RS)-3-hydroxy-4-methyl-2-p-toluenesulphonylethyliden-1-yl>-isochroman-1-one

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Technology Process of (4Z)-7-Methyl-4-<(2RS,3RS)-3-hydroxy-4-methyl-2-p-toluenesulphonylethyliden-1-yl>-isochroman-1-one

There total 6 articles about (4Z)-7-Methyl-4-<(2RS,3RS)-3-hydroxy-4-methyl-2-p-toluenesulphonylethyliden-1-yl>-isochroman-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 130767-21-4
(4Z)-7-Methyl-4-(2-p-toluenesulphonylethyliden-1-yl)-isochroman-1-one

: 78-84-2
isobutyraldehyde

: 130767-22-5
(4Z)-7-Methyl-4-<(2RS,3RS)-3-hydroxy-4-methyl-2-p-toluenesulphonylethyliden-1-yl>-isochroman-1-one

Guidance literature:: With magnesium bromide; lithium diisopropyl amide; In tetrahydrofuran; at -110 ℃; for 0.5h;
DOI:10.1016/S0040-4020(01)85578-2

Reference yield:

: 52548-14-8
2-iodoyl-5-methylbenzoic acid

: 130767-22-5
(4Z)-7-Methyl-4-<(2RS,3RS)-3-hydroxy-4-methyl-2-p-toluenesulphonylethyliden-1-yl>-isochroman-1-one

Guidance literature:: Multi-step reaction with 6 steps

1: 88 percent / AcCl / 14 h / Heating

2: 43 percent / Pd(PPh₃)2Cl₂/ ZnCl₂/ LiCl / dioxane / 48 h / Heating

3: 83 percent / 2M HCl / tetrahydrofuran / 1.75 h / Ambient temperature

4: 81 percent / NBS, PPh₃ / CH₂Cl₂ / 4.5 h / Ambient temperature

5: 61 percent / dimethylformamide / 5 h / Ambient temperature

6: 81 percent / MgBr₂, LDA / tetrahydrofuran / 0.5 h / -110 °C

With hydrogenchloride; N-Bromosuccinimide; acetyl chloride; triphenylphosphine; magnesium bromide; lithium diisopropyl amide; bis-triphenylphosphine-palladium(II) chloride; lithium chloride; zinc(II) chloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)85578-2

Reference yield:

: 103440-52-4
methyl 2-iodo-5-methylbenzoate

: 130767-22-5
(4Z)-7-Methyl-4-<(2RS,3RS)-3-hydroxy-4-methyl-2-p-toluenesulphonylethyliden-1-yl>-isochroman-1-one

Guidance literature:: Multi-step reaction with 5 steps

1: 43 percent / Pd(PPh₃)2Cl₂/ ZnCl₂/ LiCl / dioxane / 48 h / Heating

2: 83 percent / 2M HCl / tetrahydrofuran / 1.75 h / Ambient temperature

3: 81 percent / NBS, PPh₃ / CH₂Cl₂ / 4.5 h / Ambient temperature

4: 61 percent / dimethylformamide / 5 h / Ambient temperature

5: 81 percent / MgBr₂, LDA / tetrahydrofuran / 0.5 h / -110 °C

With hydrogenchloride; N-Bromosuccinimide; triphenylphosphine; magnesium bromide; lithium diisopropyl amide; bis-triphenylphosphine-palladium(II) chloride; lithium chloride; zinc(II) chloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)85578-2