2-phenylaminobenzoic acid 2,5-dioxopyrrolidin-1-yl ester

Base Information

• Chemical Name: 2-phenylaminobenzoic acid 2,5-dioxopyrrolidin-1-yl ester
• CAS No.: 262435-90-5
• Molecular Formula: C₁₇H₁₄N₂O₄
• Molecular Weight: 310.309
• Mol file: 262435-90-5.mol

Synonyms:2-phenylaminobenzoic acid 2,5-dioxopyrrolidin-1-yl ester

Chemical Property of 2-phenylaminobenzoic acid 2,5-dioxopyrrolidin-1-yl ester

Chemical Property:

Purity/Quality:

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Technology Process of 2-phenylaminobenzoic acid 2,5-dioxopyrrolidin-1-yl ester

There total 1 articles about 2-phenylaminobenzoic acid 2,5-dioxopyrrolidin-1-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + 2-(phenylamino)benzoic acid (91-40-7) → 2-phenylaminobenzoic acid 2,5-dioxopyrrolidin-1-yl ester (262435-90-5)

Guidance literature:

With dicyclohexyl-carbodiimide; In 1,2-dimethoxyethane; at 20 ℃; for 24h;

DOI:10.1248/cpb.48.211

Reference yield: 74.0%

ethyl 3-oxo-3-phenylpropionate (94-02-0) + 2-phenylaminobenzoic acid 2,5-dioxopyrrolidin-1-yl ester (262435-90-5) → 1,4-dihydro-1,2-diphenyl-4-oxoquinoline-3-carboxylic acid ethyl ester

Guidance literature:

ethyl 3-oxo-3-phenylpropionate; With sodium hydride; In benzene; at 20 ℃; for 1h;

2-phenylaminobenzoic acid 2,5-dioxopyrrolidin-1-yl ester; In benzene; at 20 - 80 ℃; for 3h;

DOI:10.1248/cpb.48.211

Reference yield: 72.0%

ethyl acetoacetate (141-97-9) + 2-phenylaminobenzoic acid 2,5-dioxopyrrolidin-1-yl ester (262435-90-5) → 1,4-dihydro-2-methyl-4-oxo-1-phenylquinoline-3-carboxylic acid ethyl ester

Guidance literature:

ethyl acetoacetate; With sodium hydride; In benzene; at 20 ℃; for 1h;

2-phenylaminobenzoic acid 2,5-dioxopyrrolidin-1-yl ester; In benzene; at 20 - 80 ℃; for 3h;

DOI:10.1248/cpb.48.211

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

2-(phenylamino)benzoic acid