2-[o-(1-butyl-2,2-difluorovinyl)phenyl]ethyl methanesulfonate

Base Information

• Chemical Name: 2-[o-(1-butyl-2,2-difluorovinyl)phenyl]ethyl methanesulfonate
• CAS No.: 772339-84-1
• Molecular Formula: C₁₅H₂₀F₂O₃S
• Molecular Weight: 318.385
• Mol file: 772339-84-1.mol

Synonyms:2-[o-(1-butyl-2,2-difluorovinyl)phenyl]ethyl methanesulfonate

Chemical Property of 2-[o-(1-butyl-2,2-difluorovinyl)phenyl]ethyl methanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[o-(1-butyl-2,2-difluorovinyl)phenyl]ethyl methanesulfonate

There total 1 articles about 2-[o-(1-butyl-2,2-difluorovinyl)phenyl]ethyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

tributyl borane (122-56-5) + 2,2,2-Trifluoroethyl p-toluenesulfonate (433-06-7) + 2-(o-iodophenyl)ethyl methanesulfonate (181717-12-4) → 2-[o-(1-butyl-2,2-difluorovinyl)phenyl]ethyl methanesulfonate (772339-84-1)

Guidance literature:

2,2,2-Trifluoroethyl p-toluenesulfonate; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.333333h;

tributyl borane; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 4h;

2-(o-iodophenyl)ethyl methanesulfonate; With N,N,N,N,N,N-hexamethylphosphoric triamide; copper(l) iodide; triphenylphosphine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In tetrahydrofuran; hexane; at 20 ℃; for 6h;

DOI:10.1016/j.jfluchem.2004.01.004

Reference yield: 71.0%

2-[o-(1-butyl-2,2-difluorovinyl)phenyl]ethyl methanesulfonate (772339-84-1) → α-butyl-β,β-difluoro-o-(2-iodoethyl)styrene (772339-85-2)

Guidance literature:

With sodium iodide; In acetone; at 20 ℃; for 14h;

DOI:10.1016/j.jfluchem.2004.01.004

Reference yield:

2-[o-(1-butyl-2,2-difluorovinyl)phenyl]ethyl methanesulfonate (772339-84-1) → 3-[o-(1-butyl-2,2-difluorovinyl)phenyl]propanitrile (772339-86-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 71 percent / NaI / acetone / 14 h / 20 °C

2: 82 percent / 18-crown-6 / acetonitrile / 10 h / Heating

With 18-crown-6 ether; sodium iodide; In acetone; acetonitrile;

DOI:10.1016/j.jfluchem.2004.01.004

upstream raw materials:

tributyl borane

2,2,2-Trifluoroethyl p-toluenesulfonate

2-(o-iodophenyl)ethyl methanesulfonate

Downstream raw materials:

α-butyl-β,β-difluoro-o-(2-iodoethyl)styrene

3-[o-(1-butyl-2,2-difluorovinyl)phenyl]propanitrile