tert-butyl 5-allyl-8-[methyl(phenylsulfonyl)amino]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-2-carboxylate

Base Information

Chemical Name:tert-butyl 5-allyl-8-[methyl(phenylsulfonyl)amino]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-2-carboxylate
CAS No.:910800-90-7
Molecular Formula:C₂₆H₃₁N₃O₄S
Molecular Weight:481.616
Hs Code.:

Synonyms:tert-butyl 5-allyl-8-[methyl(phenylsulfonyl)amino]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-2-carboxylate

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Chemical Property of tert-butyl 5-allyl-8-[methyl(phenylsulfonyl)amino]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-2-carboxylate

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Technology Process of tert-butyl 5-allyl-8-[methyl(phenylsulfonyl)amino]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-2-carboxylate

There total 9 articles about tert-butyl 5-allyl-8-[methyl(phenylsulfonyl)amino]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 910800-89-4
tert-butyl 5-allyl-8-(methylamino)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-2-carboxylate

: 98-09-9
benzenesulfonyl chloride

: 910800-90-7
tert-butyl 5-allyl-8-[methyl(phenylsulfonyl)amino]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-2-carboxylate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 300715-96-2
2-(tert-butoxycarbonyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-8-carboxylic acid

: 910800-90-7
tert-butyl 5-allyl-8-[methyl(phenylsulfonyl)amino]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide

2.1: diphenyl phosphoryl azide; triethylamine / toluene / 6 h / 100 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

3.2: 3 h / 20 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C

5.1: triethylamine / dichloromethane / 20 °C

With diphenyl phosphoryl azide; tetrabutyl ammonium fluoride; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 24589-77-3,52455-33-1
4-hydrazinobenzoic acid hydrochloride

: 910800-90-7
tert-butyl 5-allyl-8-[methyl(phenylsulfonyl)amino]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-2-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride / 1,4-dioxane; water / Heating / reflux

1.2: 20 °C / pH ~ 9 - 10

1.3: pH ~ 5

2.1: sodium hydride / N,N-dimethyl-formamide

3.1: diphenyl phosphoryl azide; triethylamine / toluene / 6 h / 100 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

4.2: 3 h / 20 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C

6.1: triethylamine / dichloromethane / 20 °C

With hydrogenchloride; diphenyl phosphoryl azide; tetrabutyl ammonium fluoride; sodium hydride; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; toluene;