1,3,4,5-TETRAHYDRO-PYRIDO[4,3-B]INDOLE-2,8-DICARBOXYLIC ACID 2-TERT-BUTYL ESTER

Base Information

• Chemical Name: 1,3,4,5-TETRAHYDRO-PYRIDO[4,3-B]INDOLE-2,8-DICARBOXYLIC ACID 2-TERT-BUTYL ESTER
• CAS No.: 300715-96-2
• Molecular Formula: C17H20 N2 O4
• Molecular Weight: 316.357
• Hs Code.: 2933990090
• Mol file: 300715-96-2.mol

Synonyms:1,3,4,5-TETRAHYDRO-PYRIDO[4,3-B]INDOLE-2,8-DICARBOXYLIC ACID 2-TERT-BUTYL ESTER

Chemical Property of 1,3,4,5-TETRAHYDRO-PYRIDO[4,3-B]INDOLE-2,8-DICARBOXYLIC ACID 2-TERT-BUTYL ESTER

Chemical Property:

• Boiling Point: 528.5±50.0 °C(Predicted)
• PKA: 4.46±0.20(Predicted)
• PSA: 82.63000
• Density: 1.321±0.06 g/cm3(Predicted)
• LogP: 3.09720
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

2-(tert-Butoxycarbonyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-8-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,3,4,5-TETRAHYDRO-PYRIDO[4,3-B]INDOLE-2,8-DICARBOXYLIC ACID 2-TERT-BUTYL ESTER

There total 5 articles about 1,3,4,5-TETRAHYDRO-PYRIDO[4,3-B]INDOLE-2,8-DICARBOXYLIC ACID 2-TERT-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-8-carboxylic acid (929345-60-8) + di-tert-butyl dicarbonate (24424-99-5) → 2-(tert-butoxycarbonyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-8-carboxylic acid (300715-96-2)

Guidance literature:

With sodium hydroxide; In methanol; water; at 20 ℃; pH=9 - 10;

DOI:10.1021/jm401582c

Reference yield: 48.7%

di-tert-butyl dicarbonate (24424-99-5) + 4-hydrazinobenzoic acid hydrochloride (24589-77-3,52455-33-1) + piperidine-4,4-diol hydrochloride (40064-34-4) → 2-(tert-butoxycarbonyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-8-carboxylic acid (300715-96-2)

Guidance literature:

4-hydrazinobenzoic acid hydrochloride; piperidine-4,4-diol hydrochloride; With hydrogenchloride; In 1,4-dioxane; water; Heating / reflux;

di-tert-butyl dicarbonate; With sodium hydroxide; In methanol; at 20 ℃; pH=~ 9 - 10;

With acetic acid; In water; pH=~ 5;

Reference yield:

4-Hydrazinobenzoic acid (619-67-0) → 2-(tert-butoxycarbonyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-8-carboxylic acid (300715-96-2)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane; water / Reflux

2: sodium hydroxide

With hydrogenchloride; sodium hydroxide; In 1,4-dioxane; water;

DOI:10.1016/j.bmcl.2011.12.124

upstream raw materials:

di-tert-butyl dicarbonate

4-hydrazinobenzoic acid hydrochloride

piperidine-4,4-diol hydrochloride

2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-8-carboxylic acid

Downstream raw materials:

8-benzyl 2-tert-butyl 1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2,8-dicarboxylate

tert-butyl 8-[(4-methylpiperidin-1-yl)carbonyl]-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxylate

C₂₈H₃₃N₃O

tert-butyl 8-[(4-methylpiperidin-1-yl)carbonyl]-5-(phenylsulfonyl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxylate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 300715-96-2 1,3,4,5-TETRAHYDRO-PYRIDO[4,3-B]INDOLE-2,8-DICARBOXYLIC ACID 2-TERT-BUTYL ESTER

Send

Send

Metric Ton KG G Pound L ML

Send

Send