[4-(4-butyryl-5-methyl-pyrazol-1-yl)phenyl]-5-methoxy-1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide hydrochloride

Base Information

Chemical Name:[4-(4-butyryl-5-methyl-pyrazol-1-yl)phenyl]-5-methoxy-1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide hydrochloride
CAS No.:1404536-52-2
Molecular Formula:C₃₁H₃₆N₆O₄*ClH
Molecular Weight:593.126
Hs Code.:

Synonyms:[4-(4-butyryl-5-methyl-pyrazol-1-yl)phenyl]-5-methoxy-1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide hydrochloride

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Chemical Property of [4-(4-butyryl-5-methyl-pyrazol-1-yl)phenyl]-5-methoxy-1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide hydrochloride

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Technology Process of [4-(4-butyryl-5-methyl-pyrazol-1-yl)phenyl]-5-methoxy-1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide hydrochloride

There total 21 articles about [4-(4-butyryl-5-methyl-pyrazol-1-yl)phenyl]-5-methoxy-1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 109-01-3
1-methyl-piperazine

: 1404532-97-3
sodium {3-[4-(4-butyryl-5-methyl-pyrazol-1-yl)phenylcarbamoyl]-5-methoxy-indol-1-yl}acetate

: 1404536-52-2
[4-(4-butyryl-5-methyl-pyrazol-1-yl)phenyl]-5-methoxy-1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide hydrochloride

Guidance literature:: 1-methyl-piperazine; sodium {3-[4-(4-butyryl-5-methyl-pyrazol-1-yl)phenylcarbamoyl]-5-methoxy-indol-1-yl}acetate; With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; In dichloromethane; at 20 ℃;

With hydrogenchloride; In diethyl ether; dichloromethane; acetone;
DOI:10.1021/jm500588w

Reference yield:

: 1404532-65-5
{3-[4-(4-butyryl-5-methyl-pyrazol-1-yl)phenylcarbamoyl]-5-methoxy-indol-1-yl}acetic acid methyl ester

: 1404536-52-2
[4-(4-butyryl-5-methyl-pyrazol-1-yl)phenyl]-5-methoxy-1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide; water / methanol

2: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride / dichloromethane / 20 °C

With water; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium hydroxide; In methanol; dichloromethane;
DOI:10.1021/jm500588w

Reference yield:

: 1006-94-6
5-methoxylindole

: 1404536-52-2
[4-(4-butyryl-5-methyl-pyrazol-1-yl)phenyl]-5-methoxy-1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: diethyl ether / -5 °C

2.1: potassium hydroxide; water / Reflux

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / -10 - 20 °C

3.2: 20 °C

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / 1,2-dichloro-ethane / 20 °C

5.1: sodium hydroxide; water / methanol

6.1: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride / dichloromethane / 20 °C

With dmap; water; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; sodium hydroxide; In methanol; diethyl ether; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm500588w