sodium {3-[4-(4-butyryl-5-methyl-pyrazol-1-yl)phenylcarbamoyl]-5-methoxy-indol-1-yl}acetate

Base Information

Chemical Name:sodium {3-[4-(4-butyryl-5-methyl-pyrazol-1-yl)phenylcarbamoyl]-5-methoxy-indol-1-yl}acetate
CAS No.:1404532-97-3
Molecular Formula:C₂₆H₂₅N₄O₅*Na
Molecular Weight:496.498
Hs Code.:

Synonyms:sodium {3-[4-(4-butyryl-5-methyl-pyrazol-1-yl)phenylcarbamoyl]-5-methoxy-indol-1-yl}acetate

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Chemical Property of sodium {3-[4-(4-butyryl-5-methyl-pyrazol-1-yl)phenylcarbamoyl]-5-methoxy-indol-1-yl}acetate

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Technology Process of sodium {3-[4-(4-butyryl-5-methyl-pyrazol-1-yl)phenylcarbamoyl]-5-methoxy-indol-1-yl}acetate

There total 20 articles about sodium {3-[4-(4-butyryl-5-methyl-pyrazol-1-yl)phenylcarbamoyl]-5-methoxy-indol-1-yl}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1404532-65-5
{3-[4-(4-butyryl-5-methyl-pyrazol-1-yl)phenylcarbamoyl]-5-methoxy-indol-1-yl}acetic acid methyl ester

: 1404532-97-3
sodium {3-[4-(4-butyryl-5-methyl-pyrazol-1-yl)phenylcarbamoyl]-5-methoxy-indol-1-yl}acetate

Guidance literature:: With water; sodium hydroxide; In methanol;
DOI:10.1021/jm500588w

Reference yield:

: 1006-94-6
5-methoxylindole

: 1404532-97-3
sodium {3-[4-(4-butyryl-5-methyl-pyrazol-1-yl)phenylcarbamoyl]-5-methoxy-indol-1-yl}acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: diethyl ether / -5 °C

2.1: potassium hydroxide; water / Reflux

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / -10 - 20 °C

3.2: 20 °C

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / 1,2-dichloro-ethane / 20 °C

5.1: sodium hydroxide; water / methanol

With dmap; water; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; sodium hydroxide; In methanol; diethyl ether; 1,2-dichloro-ethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm500588w

Reference yield:

: methyl 5-methyl-1H-pyrazole-4-carboxylate

: 1404532-97-3
sodium {3-[4-(4-butyryl-5-methyl-pyrazol-1-yl)phenylcarbamoyl]-5-methoxy-indol-1-yl}acetate

Guidance literature:: Multi-step reaction with 9 steps

1: potassium carbonate / N,N-dimethyl-formamide / 120 h / 20 °C

2: potassium hydroxide; water / ethanol / 6 h / Reflux

3: dmap; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride / dichloromethane / 1 h / 20 °C

4: diethyl ether; tetrahydrofuran / 4 h / -30 - 20 °C

5: hydrogenchloride / water; 1,4-dioxane / 6 h

6: sodium hydride / N,N-dimethyl-formamide; mineral oil / 16 h / 20 °C

7: palladium 10% on activated carbon / ethanol; cyclohexane / 4 h / Inert atmosphere; Reflux

8: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / 1,2-dichloro-ethane / 20 °C

9: sodium hydroxide; water / methanol

With hydrogenchloride; dmap; palladium 10% on activated carbon; water; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium hydride; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; ethanol; dichloromethane; cyclohexane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm500588w