diethyl [3,5-dimethyl-4-(4'-hydroxy-3'-iso-propylcarbamoylbenzyl)-phenoxy]methylphosphonic acid

Base Information

Chemical Name:diethyl [3,5-dimethyl-4-(4'-hydroxy-3'-iso-propylcarbamoylbenzyl)-phenoxy]methylphosphonic acid
CAS No.:852949-24-7
Molecular Formula:C₂₄H₃₄NO₆P
Molecular Weight:463.511
Hs Code.:

Synonyms:diethyl [3,5-dimethyl-4-(4'-hydroxy-3'-iso-propylcarbamoylbenzyl)-phenoxy]methylphosphonic acid

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Chemical Property of diethyl [3,5-dimethyl-4-(4'-hydroxy-3'-iso-propylcarbamoylbenzyl)-phenoxy]methylphosphonic acid

Chemical Property:

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Technology Process of diethyl [3,5-dimethyl-4-(4'-hydroxy-3'-iso-propylcarbamoylbenzyl)-phenoxy]methylphosphonic acid

There total 8 articles about diethyl [3,5-dimethyl-4-(4'-hydroxy-3'-iso-propylcarbamoylbenzyl)-phenoxy]methylphosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 852949-22-5
diethyl [3,5-dimethyl-4-(3'-carboxyl-4'-hydroxybenzyl)phenoxy]methylphosphonate

: 75-31-0
isopropylamine

: 852949-24-7
diethyl [3,5-dimethyl-4-(4'-hydroxy-3'-iso-propylcarbamoylbenzyl)-phenoxy]methylphosphonic acid

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

: 852949-17-8
(2,6-dimethyl-4-triisopropylsilanyloxyphenyl)-(4-methoxymethoxyphenyl)methanol

: 852949-24-7
diethyl [3,5-dimethyl-4-(4'-hydroxy-3'-iso-propylcarbamoylbenzyl)-phenoxy]methylphosphonic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogen / palladium on activated charcoal / acetic acid; ethyl acetate / 5 h / 20 °C / 760.05 Torr

2.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran; diethyl ether / 1 h / -20 - 0 °C

2.2: 2 h / 0 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 - 20 °C

4.1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

5.1: sodium chlorite; sodium dihydrogenphosphate; dihydrogen peroxide / tetrahydrofuran; water / 0.5 h / 20 °C

6.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C

With sodium chlorite; sodium dihydrogenphosphate; n-butyllithium; 1-hydroxy-7-aza-benzotriazole; N,N,N,N,-tetramethylethylenediamine; tetrabutyl ammonium fluoride; hydrogen; dihydrogen peroxide; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 6515-21-5
4-methoxymethoxy-benzaldehyde

: 852949-24-7
diethyl [3,5-dimethyl-4-(4'-hydroxy-3'-iso-propylcarbamoylbenzyl)-phenoxy]methylphosphonic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C

1.2: 1 h / -78 °C

2.1: hydrogen / palladium on activated charcoal / acetic acid; ethyl acetate / 5 h / 20 °C / 760.05 Torr

3.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran; diethyl ether / 1 h / -20 - 0 °C

3.2: 2 h / 0 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 - 20 °C

5.1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

6.1: sodium chlorite; sodium dihydrogenphosphate; dihydrogen peroxide / tetrahydrofuran; water / 0.5 h / 20 °C

7.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C

With sodium chlorite; sodium dihydrogenphosphate; n-butyllithium; 1-hydroxy-7-aza-benzotriazole; N,N,N,N,-tetramethylethylenediamine; tetrabutyl ammonium fluoride; hydrogen; dihydrogen peroxide; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide;