3-(3-(4-chloro-3-(((1-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)cyclopropyl)amino)methyl)phenyl)propyl)-1-methyl-1-((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)urea trifluoroacetate

Base Information

Chemical Name:3-(3-(4-chloro-3-(((1-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)cyclopropyl)amino)methyl)phenyl)propyl)-1-methyl-1-((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)urea trifluoroacetate
CAS No.:1445982-09-1
Molecular Formula:C₂HF₃O₂*C₃₃H₄₆ClN₅O₇
Molecular Weight:774.234
Hs Code.:

3-(3-(4-chloro-3-(((1-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)cyclopropyl)amino)methyl)phenyl)propyl)-1-methyl-1-((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)urea trifluoroacetate

Synonyms:3-(3-(4-chloro-3-(((1-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)cyclopropyl)amino)methyl)phenyl)propyl)-1-methyl-1-((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)urea trifluoroacetate

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Chemical Property of 3-(3-(4-chloro-3-(((1-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)cyclopropyl)amino)methyl)phenyl)propyl)-1-methyl-1-((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)urea trifluoroacetate

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Technology Process of 3-(3-(4-chloro-3-(((1-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)cyclopropyl)amino)methyl)phenyl)propyl)-1-methyl-1-((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)urea trifluoroacetate

There total 14 articles about 3-(3-(4-chloro-3-(((1-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)cyclopropyl)amino)methyl)phenyl)propyl)-1-methyl-1-((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)urea trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 74124-79-1
di(succinimido) carbonate

: 1445982-07-9
(1-((5-(3-aminopropyl)-2-chlorobenzyl)amino)cyclopropyl)(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)methanone trifluoroacetate

: 6284-40-8,97780-33-1
1-deoxy-1-(methylamino)-D-glucitol

: 76-05-1
trifluoroacetic acid

: 1445982-09-1
3-(3-(4-chloro-3-(((1-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)cyclopropyl)amino)methyl)phenyl)propyl)-1-methyl-1-((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)urea trifluoroacetate

Guidance literature:: di(succinimido) carbonate; (1-((5-(3-aminopropyl)-2-chlorobenzyl)amino)cyclopropyl)(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)methanone trifluoroacetate; 1-deoxy-1-(methylamino)-D-glucitol; In tetrahydrofuran; at 20 - 60 ℃;

trifluoroacetic acid;

Reference yield:

: 1445984-88-2
t-butyl (1-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)cyclopropyl)carbamate

: 1445982-09-1
3-(3-(4-chloro-3-(((1-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)cyclopropyl)amino)methyl)phenyl)propyl)-1-methyl-1-((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)urea trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride / 1,4-dioxane

2: N-ethyl-N,N-diisopropylamine; potassium iodide / acetonitrile

3: hydrogenchloride / 1,4-dioxane / 0.5 h / 20 °C

4: tetrahydrofuran / 20 - 60 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; potassium iodide; In tetrahydrofuran; 1,4-dioxane; acetonitrile;

Reference yield:

: 1224640-11-2
1-cyclopropyl-4-hydroxy-1,2,3,4-tetrahydroquinoxaline-2,3-dione

: 1445982-09-1
3-(3-(4-chloro-3-(((1-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)cyclopropyl)amino)methyl)phenyl)propyl)-1-methyl-1-((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)urea trifluoroacetate

Guidance literature:: Multi-step reaction with 7 steps

1: triphenylphosphine / N,N-dimethyl-formamide / 2 h / 135 °C / Inert atmosphere

2: borane-THF / tetrahydrofuran / 4 h / 50 °C

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 - 50 °C

4: hydrogenchloride / 1,4-dioxane

5: N-ethyl-N,N-diisopropylamine; potassium iodide / acetonitrile

6: hydrogenchloride / 1,4-dioxane / 0.5 h / 20 °C

7: tetrahydrofuran / 20 - 60 °C

With hydrogenchloride; borane-THF; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; potassium iodide; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; acetonitrile;