(1-((5-(3-aminopropyl)-2-chlorobenzyl)amino)cyclopropyl)(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)methanone trifluoroacetate

Base Information

Chemical Name:(1-((5-(3-aminopropyl)-2-chlorobenzyl)amino)cyclopropyl)(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)methanone trifluoroacetate
CAS No.:1445982-07-9
Molecular Formula:C₂HF₃O₂*C₂₅H₃₁ClN₄O
Molecular Weight:553.024
Hs Code.:

Synonyms:(1-((5-(3-aminopropyl)-2-chlorobenzyl)amino)cyclopropyl)(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)methanone trifluoroacetate

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Chemical Property of (1-((5-(3-aminopropyl)-2-chlorobenzyl)amino)cyclopropyl)(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)methanone trifluoroacetate

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Technology Process of (1-((5-(3-aminopropyl)-2-chlorobenzyl)amino)cyclopropyl)(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)methanone trifluoroacetate

There total 12 articles about (1-((5-(3-aminopropyl)-2-chlorobenzyl)amino)cyclopropyl)(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)methanone trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1445984-88-2
t-butyl (1-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)cyclopropyl)carbamate

: 1445982-07-9
(1-((5-(3-aminopropyl)-2-chlorobenzyl)amino)cyclopropyl)(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)methanone trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / 1,4-dioxane

2: N-ethyl-N,N-diisopropylamine; potassium iodide / acetonitrile

3: hydrogenchloride / 1,4-dioxane / 0.5 h / 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; potassium iodide; In 1,4-dioxane; acetonitrile;

Reference yield:

: 1224640-11-2
1-cyclopropyl-4-hydroxy-1,2,3,4-tetrahydroquinoxaline-2,3-dione

: 1445982-07-9
(1-((5-(3-aminopropyl)-2-chlorobenzyl)amino)cyclopropyl)(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)methanone trifluoroacetate

Guidance literature:: Multi-step reaction with 6 steps

1: triphenylphosphine / N,N-dimethyl-formamide / 2 h / 135 °C / Inert atmosphere

2: borane-THF / tetrahydrofuran / 4 h / 50 °C

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 - 50 °C

4: hydrogenchloride / 1,4-dioxane

5: N-ethyl-N,N-diisopropylamine; potassium iodide / acetonitrile

6: hydrogenchloride / 1,4-dioxane / 0.5 h / 20 °C

With hydrogenchloride; borane-THF; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; potassium iodide; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1224640-12-3
1-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-2,3-dione

: 1445982-07-9
(1-((5-(3-aminopropyl)-2-chlorobenzyl)amino)cyclopropyl)(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)methanone trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1: borane-THF / tetrahydrofuran / 4 h / 50 °C

2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 - 50 °C

3: hydrogenchloride / 1,4-dioxane

4: N-ethyl-N,N-diisopropylamine; potassium iodide / acetonitrile

5: hydrogenchloride / 1,4-dioxane / 0.5 h / 20 °C

With hydrogenchloride; borane-THF; N-ethyl-N,N-diisopropylamine; HATU; potassium iodide; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; acetonitrile;