4-(4-methoxy-phenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydro-quinoline-3-carboxylic acid ethyl ester

Base Information

• Chemical Name: 4-(4-methoxy-phenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydro-quinoline-3-carboxylic acid ethyl ester
• CAS No.: 33322-95-1
• Molecular Formula: C₂₀H₂₃NO₄
• Molecular Weight: 341.407
• Mol file: 33322-95-1.mol

Synonyms:4-(4-methoxy-phenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydro-quinoline-3-carboxylic acid ethyl ester

Chemical Property of 4-(4-methoxy-phenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydro-quinoline-3-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-methoxy-phenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydro-quinoline-3-carboxylic acid ethyl ester

There total 3 articles about 4-(4-methoxy-phenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydro-quinoline-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

ethyl acetoacetate (141-97-9) + 1,3-cylohexanedione (504-02-9) + 4-methoxy-benzaldehyde (123-11-5) → 4-(4-methoxy-phenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydro-quinoline-3-carboxylic acid ethyl ester (33322-95-1)

Guidance literature:

With Cu(OTf)2; ammonium acetate; In ethanol; at 100 ℃; for 0.25h; Microwave irradiation;

DOI:10.1021/cc100060s

Reference yield:

ammonium acetate (631-61-8,92206-38-7) + ethyl acetoacetate (141-97-9) + 1,3-cylohexanedione (504-02-9) + 4-methoxy-benzaldehyde (123-11-5) → 4-(4-methoxy-phenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydro-quinoline-3-carboxylic acid ethyl ester (33322-95-1)

Guidance literature:

With lithium perchlorate; at 70 ℃; for 1.5h; Green chemistry;

Reference yield:

→ 4-(4-methoxy-phenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydro-quinoline-3-carboxylic acid ethyl ester (33322-95-1)

Guidance literature:

4-Methoxy-benzaldehyd, 3-Amino-crotonsaeure-ethylester, Cyclohexan-1,3-dion, A., Eg., erhitzen;

DOI:10.1039/jr9630004877

upstream raw materials:

ethyl acetoacetate

1,3-cylohexanedione

4-methoxy-benzaldehyde

ammonium acetate

Downstream raw materials:

4-(4-methoxy-phenyl)-2-methyl-5-oxo-5,6,7,8-tetrahydro-quinoline-3-carboxylic acid ethyl ester

C₂₀H₂₃NO₄

C₂₀H₂₃NO₄