{1-[4-(4-carbamoyl-6-pyridin-2-yl-pyrrolo[2,3-d]pyrimidin-7-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester

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Chemical Name:{1-[4-(4-carbamoyl-6-pyridin-2-yl-pyrrolo[2,3-d]pyrimidin-7-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester
CAS No.:1439395-79-5
Molecular Formula:C₂₇H₂₈N₆O₃
Molecular Weight:484.558
Hs Code.:

Synonyms:{1-[4-(4-carbamoyl-6-pyridin-2-yl-pyrrolo[2,3-d]pyrimidin-7-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester

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Chemical Property of {1-[4-(4-carbamoyl-6-pyridin-2-yl-pyrrolo[2,3-d]pyrimidin-7-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester

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Technology Process of {1-[4-(4-carbamoyl-6-pyridin-2-yl-pyrrolo[2,3-d]pyrimidin-7-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester

There total 6 articles about {1-[4-(4-carbamoyl-6-pyridin-2-yl-pyrrolo[2,3-d]pyrimidin-7-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1439395-72-8
7-(4-(1-(tert-butoxycarbonylamino)cyclobutyl)phenyl)-6-(pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid

: 1439395-79-5
{1-[4-(4-carbamoyl-6-pyridin-2-yl-pyrrolo[2,3-d]pyrimidin-7-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester

Guidance literature:: With ammonia; In tetrahydrofuran; at 120 ℃; for 6h; Inert atmosphere;

Reference yield:

: 1439395-38-6
tert-butyl 1-(4-(6-chloro-5-iodopyrimidin-4-ylamino)phenyl)cyclobutylcarbamate

: 1439395-79-5
{1-[4-(4-carbamoyl-6-pyridin-2-yl-pyrrolo[2,3-d]pyrimidin-7-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 0.5 h / 80 °C / Inert atmosphere

2: caesium carbonate; bis(tri-t-butylphosphine)palladium⁽⁰⁾; potassium fluoride / 1,4-dioxane / 1 h / 130 °C / Inert atmosphere; Microwave irradiation

3: 1,1'-bis-(diphenylphosphino)ferrocene; triethylamine; palladium diacetate / N,N-dimethyl-formamide / 14 h / 80 °C / 2585.81 Torr / Inert atmosphere

4: lithium hydroxide; water / methanol / 2 h / 30 °C / Inert atmosphere

5: ammonia / tetrahydrofuran / 6 h / 120 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; 1,1'-bis-(diphenylphosphino)ferrocene; potassium fluoride; copper(l) iodide; bis(tri-t-butylphosphine)palladium⁽⁰⁾; ammonia; water; palladium diacetate; caesium carbonate; triethylamine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide;

Reference yield:

: 1439395-68-2
7-[4-(1-tert-butoxycarbonylamino-cyclobutyl)-phenyl]-6-pyridin-2-yl-7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid methyl ester

: 1439395-79-5
{1-[4-(4-carbamoyl-6-pyridin-2-yl-pyrrolo[2,3-d]pyrimidin-7-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide; water / methanol / 2 h / 30 °C / Inert atmosphere

2: ammonia / tetrahydrofuran / 6 h / 120 °C / Inert atmosphere

With ammonia; water; lithium hydroxide; In tetrahydrofuran; methanol;