7-[4-(1-tert-butoxycarbonylamino-cyclobutyl)-phenyl]-6-pyridin-2-yl-7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid methyl ester

Base Information

Chemical Name:7-[4-(1-tert-butoxycarbonylamino-cyclobutyl)-phenyl]-6-pyridin-2-yl-7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid methyl ester
CAS No.:1439395-68-2
Molecular Formula:C₂₈H₂₉N₅O₄
Molecular Weight:499.569
Hs Code.:

Synonyms:7-[4-(1-tert-butoxycarbonylamino-cyclobutyl)-phenyl]-6-pyridin-2-yl-7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid methyl ester

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Chemical Property of 7-[4-(1-tert-butoxycarbonylamino-cyclobutyl)-phenyl]-6-pyridin-2-yl-7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid methyl ester

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Technology Process of 7-[4-(1-tert-butoxycarbonylamino-cyclobutyl)-phenyl]-6-pyridin-2-yl-7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid methyl ester

There total 4 articles about 7-[4-(1-tert-butoxycarbonylamino-cyclobutyl)-phenyl]-6-pyridin-2-yl-7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 67-56-1
methanol

: 201230-82-2
carbon monoxide

: 1439395-35-3
tert-butyl 1-(4-(4-chloro-6-(pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)cyclobutylcarbamate

: 1439395-68-2
7-[4-(1-tert-butoxycarbonylamino-cyclobutyl)-phenyl]-6-pyridin-2-yl-7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid methyl ester

Guidance literature:: With 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; triethylamine; In N,N-dimethyl-formamide; at 80 ℃; for 14h; under 2585.81 Torr; Inert atmosphere;

Reference yield:

: 1439395-38-6
tert-butyl 1-(4-(6-chloro-5-iodopyrimidin-4-ylamino)phenyl)cyclobutylcarbamate

: 1439395-68-2
7-[4-(1-tert-butoxycarbonylamino-cyclobutyl)-phenyl]-6-pyridin-2-yl-7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 0.5 h / 80 °C / Inert atmosphere

2: caesium carbonate; bis(tri-t-butylphosphine)palladium⁽⁰⁾; potassium fluoride / 1,4-dioxane / 1 h / 130 °C / Inert atmosphere; Microwave irradiation

3: 1,1'-bis-(diphenylphosphino)ferrocene; triethylamine; palladium diacetate / N,N-dimethyl-formamide / 14 h / 80 °C / 2585.81 Torr / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; 1,1'-bis-(diphenylphosphino)ferrocene; potassium fluoride; copper(l) iodide; bis(tri-t-butylphosphine)palladium⁽⁰⁾; palladium diacetate; caesium carbonate; triethylamine; In 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

: 1439395-40-0
tert-butyl 1-(4-(6-chloro-5-(pyridin-2-ylethynyl)pyrimidin-4-ylamino)phenyl)cyclobutylcarbamate

: 1439395-68-2
7-[4-(1-tert-butoxycarbonylamino-cyclobutyl)-phenyl]-6-pyridin-2-yl-7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate; bis(tri-t-butylphosphine)palladium⁽⁰⁾; potassium fluoride / 1,4-dioxane / 1 h / 130 °C / Inert atmosphere; Microwave irradiation

2: 1,1'-bis-(diphenylphosphino)ferrocene; triethylamine; palladium diacetate / N,N-dimethyl-formamide / 14 h / 80 °C / 2585.81 Torr / Inert atmosphere

With 1,1'-bis-(diphenylphosphino)ferrocene; potassium fluoride; bis(tri-t-butylphosphine)palladium⁽⁰⁾; palladium diacetate; caesium carbonate; triethylamine; In 1,4-dioxane; N,N-dimethyl-formamide;