7-(4-(1-(tert-butoxycarbonylamino)cyclobutyl)phenyl)-6-(pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid

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Chemical Name:7-(4-(1-(tert-butoxycarbonylamino)cyclobutyl)phenyl)-6-(pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid
CAS No.:1439395-72-8
Molecular Formula:C₂₇H₂₇N₅O₄
Molecular Weight:485.542
Hs Code.:

Synonyms:7-(4-(1-(tert-butoxycarbonylamino)cyclobutyl)phenyl)-6-(pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid

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Chemical Property of 7-(4-(1-(tert-butoxycarbonylamino)cyclobutyl)phenyl)-6-(pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid

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Technology Process of 7-(4-(1-(tert-butoxycarbonylamino)cyclobutyl)phenyl)-6-(pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid

There total 5 articles about 7-(4-(1-(tert-butoxycarbonylamino)cyclobutyl)phenyl)-6-(pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.3%

: 1439395-68-2
7-[4-(1-tert-butoxycarbonylamino-cyclobutyl)-phenyl]-6-pyridin-2-yl-7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid methyl ester

: 1439395-72-8
7-(4-(1-(tert-butoxycarbonylamino)cyclobutyl)phenyl)-6-(pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid

Guidance literature:: With water; lithium hydroxide; In methanol; at 30 ℃; for 2h; Inert atmosphere;

Reference yield:

: 1439395-38-6
tert-butyl 1-(4-(6-chloro-5-iodopyrimidin-4-ylamino)phenyl)cyclobutylcarbamate

: 1439395-72-8
7-(4-(1-(tert-butoxycarbonylamino)cyclobutyl)phenyl)-6-(pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 0.5 h / 80 °C / Inert atmosphere

2: caesium carbonate; bis(tri-t-butylphosphine)palladium⁽⁰⁾; potassium fluoride / 1,4-dioxane / 1 h / 130 °C / Inert atmosphere; Microwave irradiation

3: 1,1'-bis-(diphenylphosphino)ferrocene; triethylamine; palladium diacetate / N,N-dimethyl-formamide / 14 h / 80 °C / 2585.81 Torr / Inert atmosphere

4: lithium hydroxide; water / methanol / 2 h / 30 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; 1,1'-bis-(diphenylphosphino)ferrocene; potassium fluoride; copper(l) iodide; bis(tri-t-butylphosphine)palladium⁽⁰⁾; water; palladium diacetate; caesium carbonate; triethylamine; lithium hydroxide; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;

Reference yield:

: 1439395-35-3
tert-butyl 1-(4-(4-chloro-6-(pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)cyclobutylcarbamate

: 1439395-72-8
7-(4-(1-(tert-butoxycarbonylamino)cyclobutyl)phenyl)-6-(pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1,1'-bis-(diphenylphosphino)ferrocene; triethylamine; palladium diacetate / N,N-dimethyl-formamide / 14 h / 80 °C / 2585.81 Torr / Inert atmosphere

2: lithium hydroxide; water / methanol / 2 h / 30 °C / Inert atmosphere

With 1,1'-bis-(diphenylphosphino)ferrocene; water; palladium diacetate; triethylamine; lithium hydroxide; In methanol; N,N-dimethyl-formamide;