phenylmethyl (2S,5R)-5-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-2-methyl-1-piperidinecarboxylate

Base Information

Chemical Name:phenylmethyl (2S,5R)-5-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-2-methyl-1-piperidinecarboxylate
CAS No.:1207853-21-1
Molecular Formula:C₁₉H₂₈N₂O₄
Molecular Weight:348.442
Hs Code.:

Synonyms:phenylmethyl (2S,5R)-5-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-2-methyl-1-piperidinecarboxylate

Suppliers and Price of phenylmethyl (2S,5R)-5-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-2-methyl-1-piperidinecarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of phenylmethyl (2S,5R)-5-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-2-methyl-1-piperidinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of phenylmethyl (2S,5R)-5-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-2-methyl-1-piperidinecarboxylate

There total 8 articles about phenylmethyl (2S,5R)-5-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-2-methyl-1-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 1150618-39-5,1222491-53-3,1227916-38-2
cis/trans-tert-butyl (6-methylpiperidin-3-yl)carbamate

: 501-53-1,94274-21-2
benzyl chloroformate

: 1207853-22-2
(2R,5R)-benzyl-5-((tert-butoxycarbonyl)amino-2-methyl)piperidine-1-carboxylate

: 1207853-21-1
phenylmethyl (2S,5R)-5-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-2-methyl-1-piperidinecarboxylate

Guidance literature:: With sodium hydrogencarbonate; In tetrahydrofuran; water; at 20 ℃;

Reference yield:

: 1227917-61-4
(3R,6S)-6-methyl-1-{[(phenylmethyl)oxy]carbonyl}-3-piperidinecarboxylic acid

: 75-65-0
tert-butyl alcohol

: 1207853-21-1
phenylmethyl (2S,5R)-5-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-2-methyl-1-piperidinecarboxylate

Guidance literature:: (3R,6S)-6-methyl-1-{[(phenylmethyl)oxy]carbonyl}-3-piperidinecarboxylic acid; With diphenyl phosphoryl azide; triethylamine; In tert-butyl alcohol; at 20 ℃;

tert-butyl alcohol; at 100 ℃; for 20h; Further stages;
DOI:10.1021/jm101527u

Reference yield:

: tert-butyl ((3R,6S)-6-methylpiperidin-3-yl)carbamate (R)-2-(3,5-dinitrobenzamido)-2-phenylacetic acid salt

: 501-53-1,94274-21-2
benzyl chloroformate

: 1207853-21-1
phenylmethyl (2S,5R)-5-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-2-methyl-1-piperidinecarboxylate

Guidance literature:: tert-butyl ((3R,6S)-6-methylpiperidin-3-yl)carbamate (R)-2-(3,5-dinitrobenzamido)-2-phenylacetic acid salt; With sodium hydroxide; In tert-butyl methyl ether; water; at 10 - 25 ℃; for 1h; Inert atmosphere; Large scale;

benzyl chloroformate; With sodium hydrogencarbonate; In tert-butyl methyl ether; water; at 5 - 20 ℃; for 20h; Inert atmosphere; Large scale;
DOI:10.1021/acs.oprd.9b00198