(3S)-N-1-(tert-butoxycarbonyl)-N-4-(4-methoxybenzyl)-3-isopropyl-piperazine-2,5-dione

Base Information

Chemical Name:(3S)-N-1-(tert-butoxycarbonyl)-N-4-(4-methoxybenzyl)-3-isopropyl-piperazine-2,5-dione
CAS No.:852994-84-4
Molecular Formula:C₂₀H₂₈N₂O₅
Molecular Weight:376.453
Hs Code.:

Synonyms:(3S)-N-1-(tert-butoxycarbonyl)-N-4-(4-methoxybenzyl)-3-isopropyl-piperazine-2,5-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3S)-N-1-(tert-butoxycarbonyl)-N-4-(4-methoxybenzyl)-3-isopropyl-piperazine-2,5-dione

Chemical Property:

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Technology Process of (3S)-N-1-(tert-butoxycarbonyl)-N-4-(4-methoxybenzyl)-3-isopropyl-piperazine-2,5-dione

There total 1 articles about (3S)-N-1-(tert-butoxycarbonyl)-N-4-(4-methoxybenzyl)-3-isopropyl-piperazine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 437768-95-1
(S)-N⁽¹⁾-(p-methoxybenzyl)-6-isopropylpiperazine-2,5-dione

: 852994-84-4
(3S)-N-1-(tert-butoxycarbonyl)-N-4-(4-methoxybenzyl)-3-isopropyl-piperazine-2,5-dione

Guidance literature:: With sodium hydrogencarbonate; In ethanol; for 12h; sonification;
DOI:10.1039/b500566c

Reference yield: 52.0%

: 852994-84-4
(3S)-N-1-(tert-butoxycarbonyl)-N-4-(4-methoxybenzyl)-3-isopropyl-piperazine-2,5-dione

: 78-84-2
isobutyraldehyde

: 852994-85-5
(6S,3S,1'R)-N-1-(4-methoxybenzyl)-N-4-(tert-butoxycarbonyl)-3-(1-hydroxy-2-methylpropyl)-6-isopropyl-piperazine-2,5-dione

Guidance literature:: (3S)-N-1-(tert-butoxycarbonyl)-N-4-(4-methoxybenzyl)-3-isopropyl-piperazine-2,5-dione; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h;

isobutyraldehyde; In tetrahydrofuran; at -78 ℃; for 0.5h;
DOI:10.1039/b500566c

Reference yield:

: 852994-84-4
(3S)-N-1-(tert-butoxycarbonyl)-N-4-(4-methoxybenzyl)-3-isopropyl-piperazine-2,5-dione

: 17498-50-9,25616-14-2,31320-20-4
L-valine hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: LHMDS / tetrahydrofuran / 1 h / -78 °C

1.2: 52 percent / tetrahydrofuran / 0.5 h / -78 °C

2.1: 62 percent / KHMDS / tetrahydrofuran; toluene / 3 h / -78 - 20 °C

3.1: NaH / dimethylformamide / 0 °C

3.2: 44 percent / dimethylformamide / 6 h / 0 °C

4.1: SmI₂ / tetrahydrofuran / 0.17 h / 20 °C

4.2: 95 percent / D₂O / tetrahydrofuran / 1 h

5.1: 83 percent / aq. cerium ammonium nitrate / acetonitrile / 1 h / 20 °C

6.1: aq. HCl / 36 h / Heating

With hydrogenchloride; samarium diiodide; ammonium cerium(IV) nitrate; potassium hexamethylsilazane; sodium hydride; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1039/b500566c