methyl 4-(N-benzyl-N-(5-(trifluoromethyl)pyridin-2-yl)sulfamoyl)benzoate

Base Information

Chemical Name:methyl 4-(N-benzyl-N-(5-(trifluoromethyl)pyridin-2-yl)sulfamoyl)benzoate
CAS No.:1254207-08-3
Molecular Formula:C₂₁H₁₇F₃N₂O₄S
Molecular Weight:450.438
Hs Code.:

Synonyms:methyl 4-(N-benzyl-N-(5-(trifluoromethyl)pyridin-2-yl)sulfamoyl)benzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 4-(N-benzyl-N-(5-(trifluoromethyl)pyridin-2-yl)sulfamoyl)benzoate

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Technology Process of methyl 4-(N-benzyl-N-(5-(trifluoromethyl)pyridin-2-yl)sulfamoyl)benzoate

There total 5 articles about methyl 4-(N-benzyl-N-(5-(trifluoromethyl)pyridin-2-yl)sulfamoyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1241472-90-1
methyl 4-(N-benzylsulfamoyl)benzoate

: 52334-81-3
2-chloro-5-trifluoromethylpyridine

: 1254207-08-3
methyl 4-(N-benzyl-N-(5-(trifluoromethyl)pyridin-2-yl)sulfamoyl)benzoate

Guidance literature:: With caesium carbonate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 18 - 115 ℃; Microwave irradiation;

Reference yield:

: C₁₄H₁₁F₃N₂O₄S

: 1254207-08-3
methyl 4-(N-benzyl-N-(5-(trifluoromethyl)pyridin-2-yl)sulfamoyl)benzoate

Guidance literature:: With caesium carbonate; sodium iodide; In N,N-dimethyl-formamide; at 80 ℃;
DOI:10.1016/j.bmcl.2014.10.074

Reference yield:

: 69812-51-7
4-chlorosulfonyl-benzoic acid methyl ester

: 1254207-08-3
methyl 4-(N-benzyl-N-(5-(trifluoromethyl)pyridin-2-yl)sulfamoyl)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / tetrahydrofuran / 0 - 20 °C

2: caesium carbonate; sodium iodide / N,N-dimethyl-formamide / 80 °C

With sodium hydride; caesium carbonate; sodium iodide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2014.10.074