1,1-dimethylethyl (αS)-β-(1,1-dimethylethoxycarbonyl)-3,4-dioxo-2-(1-methylethoxy)-α-(phenylmethyloxycarbonylamino)-1-cyclobutene-1-propionate

Base Information

Chemical Name:1,1-dimethylethyl (αS)-β-(1,1-dimethylethoxycarbonyl)-3,4-dioxo-2-(1-methylethoxy)-α-(phenylmethyloxycarbonylamino)-1-cyclobutene-1-propionate
CAS No.:253353-10-5
Molecular Formula:C₂₇H₃₅NO₉
Molecular Weight:517.576
Hs Code.:

1,1-dimethylethyl (αS)-β-(1,1-dimethylethoxycarbonyl)-3,4-dioxo-2-(1-methylethoxy)-α-(phenylmethyloxycarbonylamino)-1-cyclobutene-1-propionate

Synonyms:1,1-dimethylethyl (αS)-β-(1,1-dimethylethoxycarbonyl)-3,4-dioxo-2-(1-methylethoxy)-α-(phenylmethyloxycarbonylamino)-1-cyclobutene-1-propionate

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Chemical Property of 1,1-dimethylethyl (αS)-β-(1,1-dimethylethoxycarbonyl)-3,4-dioxo-2-(1-methylethoxy)-α-(phenylmethyloxycarbonylamino)-1-cyclobutene-1-propionate

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Technology Process of 1,1-dimethylethyl (αS)-β-(1,1-dimethylethoxycarbonyl)-3,4-dioxo-2-(1-methylethoxy)-α-(phenylmethyloxycarbonylamino)-1-cyclobutene-1-propionate

There total 1 articles about 1,1-dimethylethyl (αS)-β-(1,1-dimethylethoxycarbonyl)-3,4-dioxo-2-(1-methylethoxy)-α-(phenylmethyloxycarbonylamino)-1-cyclobutene-1-propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 253353-09-2
1,1-dimethylethyl (αS)-2,3-bis(1-methylethoxy)-β-(1,1-dimethylethoxycarbonyl)-1-hydroxy-4-oxo-α-phenylmethyloxycarbonylamino-2-cyclobutene-1-propionate

: 253353-10-5
1,1-dimethylethyl (αS)-β-(1,1-dimethylethoxycarbonyl)-3,4-dioxo-2-(1-methylethoxy)-α-(phenylmethyloxycarbonylamino)-1-cyclobutene-1-propionate

Guidance literature:: With hydrogenchloride; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1021/ol990286g

Reference yield: 80.0%

: 253353-10-5
1,1-dimethylethyl (αS)-β-(1,1-dimethylethoxycarbonyl)-3,4-dioxo-2-(1-methylethoxy)-α-(phenylmethyloxycarbonylamino)-1-cyclobutene-1-propionate

: 253353-11-6
(αS)-3,4-dioxo-2-(1-methylethoxy)-α-phenylmethyloxycarbonylamino-1-cyclobutene-1-propionic acid

Guidance literature:: 1,1-dimethylethyl (αS)-β-(1,1-dimethylethoxycarbonyl)-3,4-dioxo-2-(1-methylethoxy)-α-(phenylmethyloxycarbonylamino)-1-cyclobutene-1-propionate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 12h;

With triethylamine; In dichloromethane; at 20 ℃; for 0.166667h; Further stages.;
DOI:10.1021/ol990286g

Reference yield:

: 253353-10-5
1,1-dimethylethyl (αS)-β-(1,1-dimethylethoxycarbonyl)-3,4-dioxo-2-(1-methylethoxy)-α-(phenylmethyloxycarbonylamino)-1-cyclobutene-1-propionate

: 253353-26-3
(S)-3,4-dioxo-2-hydroxy-α-phenylmethyloxycarbonylamino-1-cyclobutene-1-propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: TFA / CH₂Cl₂ / 12 h / 20 °C

1.2: 80 percent / Et₃N / CH₂Cl₂ / 0.17 h / 20 °C

2.1: 87 percent / aq. HCl / 3 h / Heating

3.1: 84 percent / NaHCO₃ / diethyl ether; H₂O / 12 h / 20 °C

With hydrogenchloride; sodium hydrogencarbonate; trifluoroacetic acid; In diethyl ether; dichloromethane; water;
DOI:10.1021/ol990286g