methyl (2'S)-N-(3-(3,4-dioxo-2-(1-methylethyloxy)-1-cyclobutenyl)-1-oxo-2-phenylmethyloxycarbonylpropyl)-L-valinate

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Chemical Name:methyl (2'S)-N-(3-(3,4-dioxo-2-(1-methylethyloxy)-1-cyclobutenyl)-1-oxo-2-phenylmethyloxycarbonylpropyl)-L-valinate
CAS No.:253353-33-2
Molecular Formula:C₂₄H₃₀N₂O₈
Molecular Weight:474.511
Hs Code.:

Synonyms:methyl (2'S)-N-(3-(3,4-dioxo-2-(1-methylethyloxy)-1-cyclobutenyl)-1-oxo-2-phenylmethyloxycarbonylpropyl)-L-valinate

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Chemical Property of methyl (2'S)-N-(3-(3,4-dioxo-2-(1-methylethyloxy)-1-cyclobutenyl)-1-oxo-2-phenylmethyloxycarbonylpropyl)-L-valinate

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Technology Process of methyl (2'S)-N-(3-(3,4-dioxo-2-(1-methylethyloxy)-1-cyclobutenyl)-1-oxo-2-phenylmethyloxycarbonylpropyl)-L-valinate

There total 2 articles about methyl (2'S)-N-(3-(3,4-dioxo-2-(1-methylethyloxy)-1-cyclobutenyl)-1-oxo-2-phenylmethyloxycarbonylpropyl)-L-valinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 253353-11-6
(αS)-3,4-dioxo-2-(1-methylethoxy)-α-phenylmethyloxycarbonylamino-1-cyclobutene-1-propionic acid

: 6306-52-1
L-valine methylester hydrochloride

: 253353-33-2
methyl (2'S)-N-(3-(3,4-dioxo-2-(1-methylethyloxy)-1-cyclobutenyl)-1-oxo-2-phenylmethyloxycarbonylpropyl)-L-valinate

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1021/ol990286g

Reference yield:

: 253353-10-5
1,1-dimethylethyl (αS)-β-(1,1-dimethylethoxycarbonyl)-3,4-dioxo-2-(1-methylethoxy)-α-(phenylmethyloxycarbonylamino)-1-cyclobutene-1-propionate

: 253353-33-2
methyl (2'S)-N-(3-(3,4-dioxo-2-(1-methylethyloxy)-1-cyclobutenyl)-1-oxo-2-phenylmethyloxycarbonylpropyl)-L-valinate

Guidance literature:: Multi-step reaction with 2 steps

1.1: TFA / CH₂Cl₂ / 12 h / 20 °C

1.2: 80 percent / Et₃N / CH₂Cl₂ / 0.17 h / 20 °C

2.1: 40 percent / EDCI*HCl; Et₃N / dimethylformamide / 12 h / 20 °C

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol990286g