1,1-dimethylethyl (αS)-2,3-bis(1-methylethoxy)-β-(1,1-dimethylethoxycarbonyl)-1-hydroxy-4-oxo-α-phenylmethyloxycarbonylamino-2-cyclobutene-1-propionate

Base Information

• Chemical Name: 1,1-dimethylethyl (αS)-2,3-bis(1-methylethoxy)-β-(1,1-dimethylethoxycarbonyl)-1-hydroxy-4-oxo-α-phenylmethyloxycarbonylamino-2-cyclobutene-1-propionate
• CAS No.: 253353-09-2
• Molecular Formula: C₃₀H₄₃NO₁₀
• Molecular Weight: 577.672
• Mol file: 253353-09-2.mol

Synonyms:1,1-dimethylethyl (αS)-2,3-bis(1-methylethoxy)-β-(1,1-dimethylethoxycarbonyl)-1-hydroxy-4-oxo-α-phenylmethyloxycarbonylamino-2-cyclobutene-1-propionate

Chemical Property of 1,1-dimethylethyl (αS)-2,3-bis(1-methylethoxy)-β-(1,1-dimethylethoxycarbonyl)-1-hydroxy-4-oxo-α-phenylmethyloxycarbonylamino-2-cyclobutene-1-propionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,1-dimethylethyl (αS)-2,3-bis(1-methylethoxy)-β-(1,1-dimethylethoxycarbonyl)-1-hydroxy-4-oxo-α-phenylmethyloxycarbonylamino-2-cyclobutene-1-propionate

There total 1 articles about 1,1-dimethylethyl (αS)-2,3-bis(1-methylethoxy)-β-(1,1-dimethylethoxycarbonyl)-1-hydroxy-4-oxo-α-phenylmethyloxycarbonylamino-2-cyclobutene-1-propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

diisopropyl squarate (61699-62-5) + 1,4-di-tert-butyl (2S)-2-{[(benzyloxy)carbonyl]amino}butanedioate (42417-76-5) → 1,1-dimethylethyl (αS)-2,3-bis(1-methylethoxy)-β-(1,1-dimethylethoxycarbonyl)-1-hydroxy-4-oxo-α-phenylmethyloxycarbonylamino-2-cyclobutene-1-propionate (253353-09-2)

Guidance literature:

1,4-di-tert-butyl (2S)-2-{[(benzyloxy)carbonyl]amino}butanedioate; With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; lithium chloride; lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 2h;

diisopropyl squarate; In tetrahydrofuran; at -45 ℃; for 1h; Further stages.;

DOI:10.1021/ol990286g

Reference yield: 63.0%

1,1-dimethylethyl (αS)-2,3-bis(1-methylethoxy)-β-(1,1-dimethylethoxycarbonyl)-1-hydroxy-4-oxo-α-phenylmethyloxycarbonylamino-2-cyclobutene-1-propionate (253353-09-2) → 1,1-dimethylethyl (αS)-β-(1,1-dimethylethoxycarbonyl)-3,4-dioxo-2-(1-methylethoxy)-α-(phenylmethyloxycarbonylamino)-1-cyclobutene-1-propionate (253353-10-5)

Guidance literature:

With hydrogenchloride; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1021/ol990286g

Reference yield:

1,1-dimethylethyl (αS)-2,3-bis(1-methylethoxy)-β-(1,1-dimethylethoxycarbonyl)-1-hydroxy-4-oxo-α-phenylmethyloxycarbonylamino-2-cyclobutene-1-propionate (253353-09-2) → C16H13NO9

Guidance literature:

With hydrogenchloride; In acetone; at 20 ℃; for 7h;

DOI:10.1021/ol990286g

upstream raw materials:

diisopropyl squarate

1,4-di-tert-butyl (2S)-2-{[(benzyloxy)carbonyl]amino}butanedioate

Downstream raw materials:

1,1-dimethylethyl (αS)-β-(1,1-dimethylethoxycarbonyl)-3,4-dioxo-2-(1-methylethoxy)-α-(phenylmethyloxycarbonylamino)-1-cyclobutene-1-propionate