N⁽²⁾-acetylfolic acid

Base Information

• Chemical Name: N⁽²⁾-acetylfolic acid
• CAS No.: 2544-29-8
• Molecular Formula: C₂₁H₂₁N₇O₇
• Molecular Weight: 483.44
• Mol file: 2544-29-8.mol

Synonyms:N⁽²⁾-acetylfolic acid

Chemical Property of N⁽²⁾-acetylfolic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N⁽²⁾-acetylfolic acid

There total 9 articles about N⁽²⁾-acetylfolic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(6-diethoxymethyl-4-oxo-3,4-dihydro-pteridin-2-yl)-acetamide (92104-52-4) → N(2)-acetylfolic acid (2544-29-8)

Guidance literature:

Multi-step reaction with 2 steps

1: aqueous formic acid

2: thio-#p-cresol

With formic acid; para-thiocresol;

DOI:10.1021/ja01628a085

Reference yield:

2-acetylamino-4-hydroxy-6-formylpteridine (29769-49-1) + N-(4-aminobenzoyl)-L-glutamic acid (4271-30-1,532-63-8) → N(2)-acetylfolic acid (2544-29-8)

Guidance literature:

With para-thiocresol;

DOI:10.1021/ja01628a085

Reference yield:

L-glutamic acid (56-86-0,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6) → N(2)-acetylfolic acid (2544-29-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 79 percent / SOCl₂ / 18 h / Ambient temperature

2: 70 percent / HOBt, DCC, DIEA / tetrahydrofuran / 48 h / -5 °C

3: 61 percent / NaOH, H₂O / methanol / 4 h / 23 °C

4: 2.) Me₂NH*BH₃ / 1.) glacial acetic acid, r.t., 15 min, 2.) glacial acetic acid, r.t., 20 min; 60 deg C, 10 min

With sodium hydroxide; thionyl chloride; dimethylamine borane; water; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol;

upstream raw materials:

2-acetylamino-4-hydroxy-6-formylpteridine

N-(4-aminobenzoyl)-L-glutamic acid

L-glutamic acid

4-(trifluoroacetamido)benzoic acid

Downstream raw materials:

folic acid

Refernces