5-[3-(3-hydroxyphenoxy)azetidin-1-yl]-5-methyl-2,2-diphenylhexanenitrile

Base Information

Chemical Name:5-[3-(3-hydroxyphenoxy)azetidin-1-yl]-5-methyl-2,2-diphenylhexanenitrile
CAS No.:931409-66-4
Molecular Formula:C₂₈H₃₀N₂O₂
Molecular Weight:426.558
Hs Code.:

Synonyms:5-[3-(3-hydroxyphenoxy)azetidin-1-yl]-5-methyl-2,2-diphenylhexanenitrile

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Chemical Property of 5-[3-(3-hydroxyphenoxy)azetidin-1-yl]-5-methyl-2,2-diphenylhexanenitrile

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Technology Process of 5-[3-(3-hydroxyphenoxy)azetidin-1-yl]-5-methyl-2,2-diphenylhexanenitrile

There total 12 articles about 5-[3-(3-hydroxyphenoxy)azetidin-1-yl]-5-methyl-2,2-diphenylhexanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 5-[3-(3-methoxy-phenoxy)azetidin-1-yl]-5-methyl-2,2-diphenyl-hexanenitrile

: 931409-66-4
5-[3-(3-hydroxyphenoxy)azetidin-1-yl]-5-methyl-2,2-diphenylhexanenitrile

Guidance literature:: With methanesulfonic acid; DL-methionine; at 20 - 30 ℃; for 144h;

Reference yield: 73.0%

: 931409-66-4
5-[3-(3-hydroxyphenoxy)azetidin-1-yl]-5-methyl-2,2-diphenylhexanenitrile

Guidance literature:

Reference yield:

: 813440-67-4
4,4-dimethyl-[1,2,3]oxathiazinane 2,2-dioxide

: 931409-66-4
5-[3-(3-hydroxyphenoxy)azetidin-1-yl]-5-methyl-2,2-diphenylhexanenitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: dmap; triethylamine / dichloromethane / 5 - 20 °C

2.1: potassium tert-butylate / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere

2.2: 4.25 h / Inert atmosphere

2.3: 2 h / 50 °C / Inert atmosphere

3.1: sodium carbonate / dichloromethane; water

3.2: 18 h / 70 °C

4.1: pyridine / -15 - 5 °C

5.1: potassium carbonate / acetonitrile / 3.5 h / 80 °C

6.1: methanesulfonic acid / 0.5 h / 20 °C / Large scale reaction

6.2: 72 h / 30 °C / Large scale reaction

With pyridine; dmap; methanesulfonic acid; potassium tert-butylate; sodium carbonate; potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1021/op200233r