2-(trimethylsilyl)ethyl [2-(N-chloroformyl-N-methylamino)-4-nitrophenyl-2,3,4-tri-O-(tert-butyldimethylsilyl)-β-D-glucopyranoside]uronate

Base Information

Chemical Name:2-(trimethylsilyl)ethyl [2-(N-chloroformyl-N-methylamino)-4-nitrophenyl-2,3,4-tri-O-(tert-butyldimethylsilyl)-β-D-glucopyranoside]uronate
CAS No.:355010-34-3
Molecular Formula:C₃₇H₆₉ClN₂O₁₀Si₄
Molecular Weight:849.757
Hs Code.:

Synonyms:2-(trimethylsilyl)ethyl [2-(N-chloroformyl-N-methylamino)-4-nitrophenyl-2,3,4-tri-O-(tert-butyldimethylsilyl)-β-D-glucopyranoside]uronate

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Chemical Property of 2-(trimethylsilyl)ethyl [2-(N-chloroformyl-N-methylamino)-4-nitrophenyl-2,3,4-tri-O-(tert-butyldimethylsilyl)-β-D-glucopyranoside]uronate

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Technology Process of 2-(trimethylsilyl)ethyl [2-(N-chloroformyl-N-methylamino)-4-nitrophenyl-2,3,4-tri-O-(tert-butyldimethylsilyl)-β-D-glucopyranoside]uronate

There total 6 articles about 2-(trimethylsilyl)ethyl [2-(N-chloroformyl-N-methylamino)-4-nitrophenyl-2,3,4-tri-O-(tert-butyldimethylsilyl)-β-D-glucopyranoside]uronate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 75-44-5
phosgene

: 355010-33-2
2-(trimethylsilyl)ethyl [2-methylamino-4-nitrophenyl-2,3,4-tri-O-(tert-butyldimethylsilyl)-β-D-glucopyranoside]uronate

: 355010-34-3
2-(trimethylsilyl)ethyl [2-(N-chloroformyl-N-methylamino)-4-nitrophenyl-2,3,4-tri-O-(tert-butyldimethylsilyl)-β-D-glucopyranoside]uronate

Guidance literature:: With triethylamine; In dichloromethane; toluene; at 0 ℃; for 0.5h;
DOI:10.1002/1099-0690(200106)2001:11<2129::AID-EJOC2129>3.0.CO;2-#

Reference yield:

: 2916-68-9
2-(Trimethylsilyl)ethanol

: 355010-34-3
2-(trimethylsilyl)ethyl [2-(N-chloroformyl-N-methylamino)-4-nitrophenyl-2,3,4-tri-O-(tert-butyldimethylsilyl)-β-D-glucopyranoside]uronate

Guidance literature:: Multi-step reaction with 2 steps

1: 39 percent / DCC; DMAP / CH₂Cl₂ / 12 h / 20 °C

2: 85 percent / Et₃N / toluene; CH₂Cl₂ / 0.5 h / 0 °C

With dmap; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; toluene;
DOI:10.1002/1099-0690(200106)2001:11<2129::AID-EJOC2129>3.0.CO;2-#

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: 355010-34-3
2-(trimethylsilyl)ethyl [2-(N-chloroformyl-N-methylamino)-4-nitrophenyl-2,3,4-tri-O-(tert-butyldimethylsilyl)-β-D-glucopyranoside]uronate

Guidance literature:: Multi-step reaction with 3 steps

1: 457 mg / DMAP / pyridine / 48 h / 20 °C

2: 39 percent / DCC; DMAP / CH₂Cl₂ / 12 h / 20 °C

3: 85 percent / Et₃N / toluene; CH₂Cl₂ / 0.5 h / 0 °C

With dmap; triethylamine; dicyclohexyl-carbodiimide; In pyridine; dichloromethane; toluene;
DOI:10.1002/1099-0690(200106)2001:11<2129::AID-EJOC2129>3.0.CO;2-#