2-chloro-4-(3-cyclopentyl-7-((R)-3-(N,N-dimethylamino)pyrrolidine-1-carbonyl)-3,3a,4,5-tetrahydro-2H-pyrazolo[3,4-f]quinolin-2-yl)benzonitrile

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Chemical Name:2-chloro-4-(3-cyclopentyl-7-((R)-3-(N,N-dimethylamino)pyrrolidine-1-carbonyl)-3,3a,4,5-tetrahydro-2H-pyrazolo[3,4-f]quinolin-2-yl)benzonitrile
CAS No.:1359969-37-1
Molecular Formula:C₂₉H₃₃ClN₆O
Molecular Weight:517.074
Hs Code.:

Synonyms:2-chloro-4-(3-cyclopentyl-7-((R)-3-(N,N-dimethylamino)pyrrolidine-1-carbonyl)-3,3a,4,5-tetrahydro-2H-pyrazolo[3,4-f]quinolin-2-yl)benzonitrile

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Chemical Property of 2-chloro-4-(3-cyclopentyl-7-((R)-3-(N,N-dimethylamino)pyrrolidine-1-carbonyl)-3,3a,4,5-tetrahydro-2H-pyrazolo[3,4-f]quinolin-2-yl)benzonitrile

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Technology Process of 2-chloro-4-(3-cyclopentyl-7-((R)-3-(N,N-dimethylamino)pyrrolidine-1-carbonyl)-3,3a,4,5-tetrahydro-2H-pyrazolo[3,4-f]quinolin-2-yl)benzonitrile

There total 4 articles about 2-chloro-4-(3-cyclopentyl-7-((R)-3-(N,N-dimethylamino)pyrrolidine-1-carbonyl)-3,3a,4,5-tetrahydro-2H-pyrazolo[3,4-f]quinolin-2-yl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1246383-56-1,864448-61-3
(R)-N,N-dimethylpyrrolidine-3-amine hydrochloride

: 1359968-92-5
2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-pyrazolo[3,4-f]quinoline-7-carboxylic acid

: 1359969-37-1
2-chloro-4-(3-cyclopentyl-7-((R)-3-(N,N-dimethylamino)pyrrolidine-1-carbonyl)-3,3a,4,5-tetrahydro-2H-pyrazolo[3,4-f]quinolin-2-yl)benzonitrile

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 24h;

Reference yield:

: 1359969-84-8
methyl 2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-pyrazolo[3,4-f]quinoline-7-carboxylate

: 1359969-37-1
2-chloro-4-(3-cyclopentyl-7-((R)-3-(N,N-dimethylamino)pyrrolidine-1-carbonyl)-3,3a,4,5-tetrahydro-2H-pyrazolo[3,4-f]quinolin-2-yl)benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide; water / methanol; tetrahydrofuran / 15 h / 20 °C

1.2: pH 2 - 3 / Cooling with ice

2.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane; N,N-dimethyl-formamide / 24 h / 20 °C

With water; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1004538-33-3
(R)-tert-butyl 3-(dimethylamino)pyrrolidine-1-carboxylate

: 1359969-37-1
2-chloro-4-(3-cyclopentyl-7-((R)-3-(N,N-dimethylamino)pyrrolidine-1-carbonyl)-3,3a,4,5-tetrahydro-2H-pyrazolo[3,4-f]quinolin-2-yl)benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / dichloromethane / 3 h

2: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane; N,N-dimethyl-formamide / 24 h / 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; N,N-dimethyl-formamide;