(R)-1-BOC-3-DIMETHYLAMINOPYRROLIDINE

Base Information

• Chemical Name: (R)-1-BOC-3-DIMETHYLAMINOPYRROLIDINE
• CAS No.: 1004538-33-3
• Molecular Formula: C₁₁H₂₂N₂O₂
• Molecular Weight: 214.308
• Hs Code.: 2933990090
• Mol file: 1004538-33-3.mol

Synonyms:(R)-1-BOC-3-DIMETHYLAMINOPYRROLIDINE;tert-butyl (3R)-3-(dimethylamino)pyrrolidine-1-carboxylate;(R)-tert-Butyl 3-(dimethylamino)pyrrolidine-1-carboxylate;

Chemical Property of (R)-1-BOC-3-DIMETHYLAMINOPYRROLIDINE

Chemical Property:

• PSA: 32.78000
• LogP: 1.49530
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

(R)-1-Boc-3-(dimethylamino)pyrrolidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-1-BOC-3-DIMETHYLAMINOPYRROLIDINE

There total 2 articles about (R)-1-BOC-3-DIMETHYLAMINOPYRROLIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(R)-1-(tert-butoxycarbonyl)-3-dimethylaminopyrrolidine hydrochloric acid salt (1004538-32-2) → (R)-tert-butyl 3-(dimethylamino)pyrrolidine-1-carboxylate (1004538-33-3)

Guidance literature:

With sodium hydroxide; water; In toluene;

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + (R)-3-aminopyrrolidine-1-carboxylic acid tert-butyl ester (147081-49-0) → (R)-tert-butyl 3-(dimethylamino)pyrrolidine-1-carboxylate (1004538-33-3)

Guidance literature:

With sodium cyanoborohydride; magnesium sulfate; acetic acid; In methanol; at 20 ℃; for 24h;

Reference yield:

(R)-tert-butyl 3-(dimethylamino)pyrrolidine-1-carboxylate (1004538-33-3) → 2-chloro-4-(3-cyclopentyl-7-((R)-3-(N,N-dimethylamino)pyrrolidine-1-carbonyl)-3,3a,4,5-tetrahydro-2H-pyrazolo[3,4-f]quinolin-2-yl)benzonitrile (1359969-37-1)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / dichloromethane / 3 h

2: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane; N,N-dimethyl-formamide / 24 h / 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

(R)-1-(tert-butoxycarbonyl)-3-dimethylaminopyrrolidine hydrochloric acid salt

formaldehyd

(R)-3-aminopyrrolidine-1-carboxylic acid tert-butyl ester

Downstream raw materials:

2-chloro-4-(3-cyclopentyl-7-((R)-3-(N,N-dimethylamino)pyrrolidine-1-carbonyl)-3,3a,4,5-tetrahydro-2H-pyrazolo[3,4-f]quinolin-2-yl)benzonitrile

Refernces

• 1、 -. "METHOD FOR PRODUCTION OF OPTICALLY ACTIVE 3-AMINO-NITROGENATED COMPOUND". Page/Page column 21-22. . Retrieved 2009/05/29.