8-[4-(4-Acetyl-3-hydroxy-2-propyl-benzyloxy)-phenyl]-8-oxo-octanenitrile

Base Information

Chemical Name:8-[4-(4-Acetyl-3-hydroxy-2-propyl-benzyloxy)-phenyl]-8-oxo-octanenitrile
CAS No.:119348-78-6
Molecular Formula:C₂₆H₃₁NO₄
Molecular Weight:421.536
Hs Code.:

Synonyms:8-[4-(4-Acetyl-3-hydroxy-2-propyl-benzyloxy)-phenyl]-8-oxo-octanenitrile

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Chemical Property of 8-[4-(4-Acetyl-3-hydroxy-2-propyl-benzyloxy)-phenyl]-8-oxo-octanenitrile

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Technology Process of 8-[4-(4-Acetyl-3-hydroxy-2-propyl-benzyloxy)-phenyl]-8-oxo-octanenitrile

There total 4 articles about 8-[4-(4-Acetyl-3-hydroxy-2-propyl-benzyloxy)-phenyl]-8-oxo-octanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 97582-36-0
1-<4-(chloromethyl)-2-hydroxy-3-propylphenyl>ethanone

: 135339-55-8
8-(4-hydroxyphenyl)-8-oxooctanenitrile

: 119348-78-6
8-[4-(4-Acetyl-3-hydroxy-2-propyl-benzyloxy)-phenyl]-8-oxo-octanenitrile

Guidance literature:: With potassium tert-butylate; sodium iodide; In ethanol; for 30h; Ambient temperature;
DOI:10.1021/jm00113a014

Reference yield:

: 20965-27-9
7-bromo-heptanonitrile

: 119348-78-6
8-[4-(4-Acetyl-3-hydroxy-2-propyl-benzyloxy)-phenyl]-8-oxo-octanenitrile

Guidance literature:: Multi-step reaction with 3 steps

1: LDA, HMPA / tetrahydrofuran; hexane / 3 h / -65 - 25 °C

2: pyridine hydrochloride / 20 h / 185 °C

3: 47 percent / potassium t-butoxide, NaI / ethanol / 30 h / Ambient temperature

With N,N,N,N,N,N-hexamethylphosphoric triamide; potassium tert-butylate; pyridine hydrochloride; sodium iodide; lithium diisopropyl amide; In tetrahydrofuran; ethanol; hexane;
DOI:10.1021/jm00113a014

Reference yield:

: 15190-05-3
2-(dimethylamino)-2-(4-methoxyphenyl)acetonitrile

: 119348-78-6
8-[4-(4-Acetyl-3-hydroxy-2-propyl-benzyloxy)-phenyl]-8-oxo-octanenitrile

Guidance literature:: Multi-step reaction with 3 steps

1: LDA, HMPA / tetrahydrofuran; hexane / 3 h / -65 - 25 °C

2: pyridine hydrochloride / 20 h / 185 °C

3: 47 percent / potassium t-butoxide, NaI / ethanol / 30 h / Ambient temperature

With N,N,N,N,N,N-hexamethylphosphoric triamide; potassium tert-butylate; pyridine hydrochloride; sodium iodide; lithium diisopropyl amide; In tetrahydrofuran; ethanol; hexane;
DOI:10.1021/jm00113a014