2-(Dimethylamino)-2-(4-methoxyphenyl)acetonitrile

Base Information

Chemical Name:2-(Dimethylamino)-2-(4-methoxyphenyl)acetonitrile
CAS No.:15190-05-3
Molecular Formula:C₁₁H₁₄N₂O
Molecular Weight:190.245
Hs Code.:
DSSTox Substance ID:DTXSID101247410
Nikkaji Number:J283.493F

Synonyms:2-(dimethylamino)-2-(4-methoxyphenyl)acetonitrile;15190-05-3;starbld0037510;DTXSID101247410;AKOS009985993;CS-10044;alpha-(Dimethylamino)-4-methoxybenzeneacetonitrile

Suppliers and Price of 2-(Dimethylamino)-2-(4-methoxyphenyl)acetonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 3 raw suppliers

Chemical Property of 2-(Dimethylamino)-2-(4-methoxyphenyl)acetonitrile

Chemical Property:

XLogP3:1.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:190.110613074
Heavy Atom Count:14
Complexity:211

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CN(C)C(C#N)C1=CC=C(C=C1)OC

Technology Process of 2-(Dimethylamino)-2-(4-methoxyphenyl)acetonitrile

There total 8 articles about 2-(Dimethylamino)-2-(4-methoxyphenyl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 7677-24-9
trimethylsilyl cyanide

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 13139-86-1
4-methoxyphenyl magnesium bromide

: 15190-05-3
2-(dimethylamino)-2-(4-methoxyphenyl)acetonitrile

Guidance literature:: trimethylsilyl cyanide; N,N-dimethyl-formamide; With titanium(IV) isopropylate; In tetrahydrofuran; for 0.166667h;

4-methoxyphenyl magnesium bromide; In tetrahydrofuran; at 20 ℃; Solvent;
DOI:10.1002/ejoc.202100418

Reference yield: 79.0%

: 33646-40-1
4-methoxymandelonitrile

: 124-40-3
dimethyl amine

: 15190-05-3
2-(dimethylamino)-2-(4-methoxyphenyl)acetonitrile

Guidance literature:: In methanol; water; for 24h; Ambient temperature;
DOI:10.1002/ardp.19823150405

Reference yield: 77.0%

: 10442-39-4
tetra-n-butylammonium cyanide

: 7291-00-1
N,N-dimethyl-4-methoxybenzamide

: 15190-05-3
2-(dimethylamino)-2-(4-methoxyphenyl)acetonitrile

Guidance literature:: N,N-dimethyl-4-methoxybenzamide; With sodium hydride; sodium iodide; In tetrahydrofuran; mineral oil; at 60 ℃; for 5h; Inert atmosphere;

tetra-n-butylammonium cyanide; With chloro-trimethyl-silane; In tetrahydrofuran; mineral oil; at 24 ℃; for 4h; Inert atmosphere;
DOI:10.1002/anie.202004272