1-{4-[(4-Acetyl-3-hydroxy-2-propylphenyl)methoxy]phenyl}-7-(1H-tetrazol-5-yl)-1-heptanone

Base Information

Chemical Name:1-{4-[(4-Acetyl-3-hydroxy-2-propylphenyl)methoxy]phenyl}-7-(1H-tetrazol-5-yl)-1-heptanone
CAS No.:119348-60-6
Molecular Formula:C₂₆H₃₂N₄O₄
Molecular Weight:464.564
Hs Code.:

Synonyms:1-{4-[(4-Acetyl-3-hydroxy-2-propylphenyl)methoxy]phenyl}-7-(1H-tetrazol-5-yl)-1-heptanone

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Chemical Property of 1-{4-[(4-Acetyl-3-hydroxy-2-propylphenyl)methoxy]phenyl}-7-(1H-tetrazol-5-yl)-1-heptanone

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Technology Process of 1-{4-[(4-Acetyl-3-hydroxy-2-propylphenyl)methoxy]phenyl}-7-(1H-tetrazol-5-yl)-1-heptanone

There total 6 articles about 1-{4-[(4-Acetyl-3-hydroxy-2-propylphenyl)methoxy]phenyl}-7-(1H-tetrazol-5-yl)-1-heptanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 119348-78-6
8-[4-(4-Acetyl-3-hydroxy-2-propyl-benzyloxy)-phenyl]-8-oxo-octanenitrile

: 119348-60-6
1-{4-[(4-Acetyl-3-hydroxy-2-propylphenyl)methoxy]phenyl}-7-(1H-tetrazol-5-yl)-1-heptanone

Guidance literature:: With tributyltin azide; In monoethylene glycol diethyl ether; for 96h; Heating;
DOI:10.1021/jm00113a014

Reference yield: 22.0%

: 119348-60-6
1-{4-[(4-Acetyl-3-hydroxy-2-propylphenyl)methoxy]phenyl}-7-(1H-tetrazol-5-yl)-1-heptanone

Guidance literature:

Reference yield:

: 20965-27-9
7-bromo-heptanonitrile

: 119348-60-6
1-{4-[(4-Acetyl-3-hydroxy-2-propylphenyl)methoxy]phenyl}-7-(1H-tetrazol-5-yl)-1-heptanone

Guidance literature:: Multi-step reaction with 4 steps

1: LDA, HMPA / tetrahydrofuran; hexane / 3 h / -65 - 25 °C

2: pyridine hydrochloride / 20 h / 185 °C

3: 47 percent / potassium t-butoxide, NaI / ethanol / 30 h / Ambient temperature

4: 23 percent / tributyltin azide / 1,2-diethoxy-ethane / 96 h / Heating

With N,N,N,N,N,N-hexamethylphosphoric triamide; tributyltin azide; potassium tert-butylate; pyridine hydrochloride; sodium iodide; lithium diisopropyl amide; In tetrahydrofuran; ethanol; hexane; monoethylene glycol diethyl ether;
DOI:10.1021/jm00113a014