N-tert-butyl-3-((4-(4-(3-(5-tert-butylisoxazol-3-yl)ureido)-3-fluorobenzoyl)piperazin-1-yl)methyl)benzamide 2,2,2-trifluoroacetate

Base Information

Chemical Name:N-tert-butyl-3-((4-(4-(3-(5-tert-butylisoxazol-3-yl)ureido)-3-fluorobenzoyl)piperazin-1-yl)methyl)benzamide 2,2,2-trifluoroacetate
CAS No.:1124213-28-0
Molecular Formula:C₂HF₃O₂*C₃₁H₃₉FN₆O₄
Molecular Weight:692.711
Hs Code.:

Synonyms:N-tert-butyl-3-((4-(4-(3-(5-tert-butylisoxazol-3-yl)ureido)-3-fluorobenzoyl)piperazin-1-yl)methyl)benzamide 2,2,2-trifluoroacetate

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Chemical Property of N-tert-butyl-3-((4-(4-(3-(5-tert-butylisoxazol-3-yl)ureido)-3-fluorobenzoyl)piperazin-1-yl)methyl)benzamide 2,2,2-trifluoroacetate

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Technology Process of N-tert-butyl-3-((4-(4-(3-(5-tert-butylisoxazol-3-yl)ureido)-3-fluorobenzoyl)piperazin-1-yl)methyl)benzamide 2,2,2-trifluoroacetate

There total 6 articles about N-tert-butyl-3-((4-(4-(3-(5-tert-butylisoxazol-3-yl)ureido)-3-fluorobenzoyl)piperazin-1-yl)methyl)benzamide 2,2,2-trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 55809-36-4
3-amino-5-tert-butylisoxazole

: 1124212-35-6
3-((4-(4-amino-3-fluorobenzoyl)piperazin-1-yl)methyl)-N-tert-butylbenzamide

: 7693-46-1
4-Nitrophenyl chloroformate

: 1124213-28-0
N-tert-butyl-3-((4-(4-(3-(5-tert-butylisoxazol-3-yl)ureido)-3-fluorobenzoyl)piperazin-1-yl)methyl)benzamide 2,2,2-trifluoroacetate

Guidance literature:: 3-((4-(4-amino-3-fluorobenzoyl)piperazin-1-yl)methyl)-N-tert-butylbenzamide; 4-Nitrophenyl chloroformate; In dichloromethane; at 20 ℃; for 0.5h;

3-amino-5-tert-butylisoxazole; With triethylamine; In dichloromethane; at 120 ℃; for 0.166667h; Microwave irradiation;

Reference yield:

: 55809-36-4
3-amino-5-tert-butylisoxazole

: 1124212-35-6
3-((4-(4-amino-3-fluorobenzoyl)piperazin-1-yl)methyl)-N-tert-butylbenzamide

: 7693-46-1
4-Nitrophenyl chloroformate

: 76-05-1
trifluoroacetic acid

: 1124213-28-0
N-tert-butyl-3-((4-(4-(3-(5-tert-butylisoxazol-3-yl)ureido)-3-fluorobenzoyl)piperazin-1-yl)methyl)benzamide 2,2,2-trifluoroacetate

Guidance literature:: 3-((4-(4-amino-3-fluorobenzoyl)piperazin-1-yl)methyl)-N-tert-butylbenzamide; 4-Nitrophenyl chloroformate; With triethylamine; In dichloromethane; at 20 ℃; for 0.5h;

3-amino-5-tert-butylisoxazole; With triethylamine; In dichloromethane; at 120 ℃; for 0.166667h; microwave irradiation;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 1094362-66-9
N-tert-butyl-3-(chloromethyl)benzamide

: 1124213-28-0
N-tert-butyl-3-((4-(4-(3-(5-tert-butylisoxazol-3-yl)ureido)-3-fluorobenzoyl)piperazin-1-yl)methyl)benzamide 2,2,2-trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 20 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 2.5 h / 60 °C

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / acetonitrile / 20 °C / Inert atmosphere

4.1: triethylamine / dichloromethane / 0.5 h / 20 °C

4.2: 0.17 h / 120 °C / microwave irradiation

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; dimethyl sulfoxide; acetonitrile;