1-[(4aS,11cS)-7-(4-Methoxy-benzenesulfonyl)-4a-methyl-2,3,4,4a,5,6,7,11c-octahydro-pyrido[3,2-c]carbazol-1-yl]-2-phenylsulfanyl-ethanone

Base Information

Chemical Name:1-[(4aS,11cS)-7-(4-Methoxy-benzenesulfonyl)-4a-methyl-2,3,4,4a,5,6,7,11c-octahydro-pyrido[3,2-c]carbazol-1-yl]-2-phenylsulfanyl-ethanone
CAS No.:128592-38-1
Molecular Formula:C₃₁H₃₂N₂O₄S₂
Molecular Weight:560.738
Hs Code.:

Synonyms:1-[(4aS,11cS)-7-(4-Methoxy-benzenesulfonyl)-4a-methyl-2,3,4,4a,5,6,7,11c-octahydro-pyrido[3,2-c]carbazol-1-yl]-2-phenylsulfanyl-ethanone

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Chemical Property of 1-[(4aS,11cS)-7-(4-Methoxy-benzenesulfonyl)-4a-methyl-2,3,4,4a,5,6,7,11c-octahydro-pyrido[3,2-c]carbazol-1-yl]-2-phenylsulfanyl-ethanone

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Technology Process of 1-[(4aS,11cS)-7-(4-Methoxy-benzenesulfonyl)-4a-methyl-2,3,4,4a,5,6,7,11c-octahydro-pyrido[3,2-c]carbazol-1-yl]-2-phenylsulfanyl-ethanone

There total 9 articles about 1-[(4aS,11cS)-7-(4-Methoxy-benzenesulfonyl)-4a-methyl-2,3,4,4a,5,6,7,11c-octahydro-pyrido[3,2-c]carbazol-1-yl]-2-phenylsulfanyl-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 128592-29-0,128598-92-5
N-{3-[(S)-4-Hydroxy-9-(4-methoxy-benzenesulfonyl)-3-methyl-2,3,4,9-tetrahydro-1H-carbazol-3-yl]-propyl}-2-phenylsulfanyl-acetamide

: 128592-38-1
1-[(4aS,11cS)-7-(4-Methoxy-benzenesulfonyl)-4a-methyl-2,3,4,4a,5,6,7,11c-octahydro-pyrido[3,2-c]carbazol-1-yl]-2-phenylsulfanyl-ethanone

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 0.166667h;
DOI:10.1016/S0040-4039(00)94654-9

Reference yield:

: 7031-27-8
(phenylthio)acetic acid chloride

: 128592-38-1
1-[(4aS,11cS)-7-(4-Methoxy-benzenesulfonyl)-4a-methyl-2,3,4,4a,5,6,7,11c-octahydro-pyrido[3,2-c]carbazol-1-yl]-2-phenylsulfanyl-ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: 1N NaOH / 0.33 h / 0 °C

2: 100 percent / TFA / CH₂Cl₂ / 0.17 h / 0 °C

With sodium hydroxide; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/S0040-4039(00)94654-9

Reference yield:

: 128592-33-6
(R)-3-(3-Hydroxy-propyl)-3-methyl-1,2,3,9-tetrahydro-carbazol-4-one

: 128592-38-1
1-[(4aS,11cS)-7-(4-Methoxy-benzenesulfonyl)-4a-methyl-2,3,4,4a,5,6,7,11c-octahydro-pyrido[3,2-c]carbazol-1-yl]-2-phenylsulfanyl-ethanone

Guidance literature:: Multi-step reaction with 7 steps

1: Et₃N / CH₂Cl₂ / 1 h / 0 °C

2: NaN₃ / dimethylformamide / 3 h / 80 °C

3: 93 percent / 50percent NaOH, n-Bu₄N*HSO₄ / CH₂Cl₂ / 2 h / 20 °C

4: 80 percent / NaBH₄ / ethanol / 0.17 h / Heating

5: 1) Ph₃P 2) H₂O / 1) THF, 48h, 20 deg C

6: 1N NaOH / 0.33 h / 0 °C

7: 100 percent / TFA / CH₂Cl₂ / 0.17 h / 0 °C

With sodium hydroxide; sodium tetrahydroborate; sodium azide; water; tetra(n-butyl)ammonium hydrogensulfate; triethylamine; triphenylphosphine; trifluoroacetic acid; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)94654-9