methyl 2-methyl-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)propanoate

Base Information

Chemical Name:methyl 2-methyl-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)propanoate
CAS No.:877399-11-6
Molecular Formula:C₁₄H₂₃BN₂O₄
Molecular Weight:294.159
Hs Code.:

Synonyms:methyl 2-methyl-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)propanoate

Suppliers and Price of methyl 2-methyl-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)propanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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A1 Biochem Labs
2-Methyl-2-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrazol-1-yl]-propionicacidmethylester 95%
5 g
$ 950.00

Total 3 raw suppliers

Chemical Property of methyl 2-methyl-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)propanoate

Chemical Property:

Purity/Quality:

98%+ ^*data from raw suppliers

2-Methyl-2-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrazol-1-yl]-propionicacidmethylester 95% ^*data from reagent suppliers

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Technology Process of methyl 2-methyl-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)propanoate

There total 3 articles about methyl 2-methyl-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 269410-08-4
pyrazole-4-boronic acid pinacol ester

: 23426-63-3
2-bromo-2-methylpropionic acid methyl ester

: 877399-11-6
methyl 2-methyl-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)propanoate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 90 ℃;

Reference yield:

: 877401-10-0
methyl 2-(4-bromo-1H-pyrazol-1-yl)-2-methylpropanoate

: 73183-34-3
bis(pinacol)diborane

: 877399-11-6
methyl 2-methyl-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)propanoate

Guidance literature:: With 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex; potassium acetate; In dimethyl sulfoxide; at 80 ℃; Inert atmosphere;
DOI:10.1021/jm2007613

Reference yield:

: 23426-63-3
2-bromo-2-methylpropionic acid methyl ester

: 877399-11-6
methyl 2-methyl-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 110 °C / Inert atmosphere; Microwave irradiation

2: 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex; potassium acetate / dimethyl sulfoxide / 80 °C / Inert atmosphere

With 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex; potassium acetate; sodium hydride; In dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm2007613