2-(4-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)-2-methylpropanoic acid

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Chemical Name:2-(4-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)-2-methylpropanoic acid
CAS No.:877399-13-8
Molecular Formula:C₂₀H₁₉Cl₂FN₄O₃
Molecular Weight:453.3
Hs Code.:

Synonyms:2-(4-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)-2-methylpropanoic acid

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Chemical Property of 2-(4-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)-2-methylpropanoic acid

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Technology Process of 2-(4-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)-2-methylpropanoic acid

There total 9 articles about 2-(4-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)-2-methylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: methyl 2-(4-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)-2-methylpropanoate

: 877399-13-8
2-(4-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)-2-methylpropanoic acid

Guidance literature:: methyl 2-(4-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)-2-methylpropanoate; With methanol; lithium hydroxide; water; at 60 ℃; for 0.75h;

With hydrogenchloride; pH=5;

Reference yield:

: 756520-66-8
1-(2,6-dichloro-3-fluorophenyl)ethanol

: 877399-13-8
2-(4-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere

2.1: iron; acetic acid / ethanol / 1 h / Inert atmosphere; Reflux

3.1: N-iodo-succinimide / acetic acid; acetonitrile / 4 h / Inert atmosphere

4.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; cesium fluoride / 1,2-dimethoxyethane; water / 1 h / 120 °C / Inert atmosphere; Microwave irradiation

5.1: lithium hydroxide / methanol; water / 0.75 h / 60 °C / Inert atmosphere

5.2: pH 5 / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-iodo-succinimide; iron; acetic acid; triphenylphosphine; cesium fluoride; lithium hydroxide; diethylazodicarboxylate; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; water; acetic acid; toluene; acetonitrile; 1.1: Mitsunobu reaction / 4.1: Suzuki coupling;
DOI:10.1021/jm2007613

Reference yield:

: 756521-08-1
(±)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine

: 877399-13-8
2-(4-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: iron; acetic acid / ethanol / 1 h / Inert atmosphere; Reflux

2.1: N-iodo-succinimide / acetic acid; acetonitrile / 4 h / Inert atmosphere

3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; cesium fluoride / 1,2-dimethoxyethane; water / 1 h / 120 °C / Inert atmosphere; Microwave irradiation

4.1: lithium hydroxide / methanol; water / 0.75 h / 60 °C / Inert atmosphere

4.2: pH 5 / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-iodo-succinimide; iron; acetic acid; cesium fluoride; lithium hydroxide; In methanol; 1,2-dimethoxyethane; ethanol; water; acetic acid; acetonitrile; 3.1: Suzuki coupling;
DOI:10.1021/jm2007613