N₁-(4-amino-3-methyl-1-propyl-uracil-5-yl)-3-[6-phenyl-pyridazin-3(2H)-one-2-yl]-propanamide

Base Information

• Chemical Name: N₁-(4-amino-3-methyl-1-propyl-uracil-5-yl)-3-[6-phenyl-pyridazin-3(2H)-one-2-yl]-propanamide
• CAS No.: 346407-31-6
• Molecular Formula: C₂₁H₂₄N₆O₄
• Molecular Weight: 424.459

Synonyms:N₁-(4-amino-3-methyl-1-propyl-uracil-5-yl)-3-[6-phenyl-pyridazin-3(2H)-one-2-yl]-propanamide

Chemical Property of N₁-(4-amino-3-methyl-1-propyl-uracil-5-yl)-3-[6-phenyl-pyridazin-3(2H)-one-2-yl]-propanamide

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Technology Process of N₁-(4-amino-3-methyl-1-propyl-uracil-5-yl)-3-[6-phenyl-pyridazin-3(2H)-one-2-yl]-propanamide

There total 3 articles about N₁-(4-amino-3-methyl-1-propyl-uracil-5-yl)-3-[6-phenyl-pyridazin-3(2H)-one-2-yl]-propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

5,6-diamino-1-methyl-3-n-propyluracil (106465-68-3) + 3-[6-phenyl-pyridazin-3(2H)-one-2-yl]-propanoic acid (73402-26-3) → N1-(4-amino-3-methyl-1-propyl-uracil-5-yl)-3-[6-phenyl-pyridazin-3(2H)-one-2-yl]-propanamide (346407-31-6)

Guidance literature:

With dicyclohexyl-carbodiimide; In methanol; at 20 ℃; for 24h;

DOI:10.1016/S0968-0896(00)00271-6

Reference yield:

6-phenylpyridazin-3(2H)-one (2166-31-6) → N1-(4-amino-3-methyl-1-propyl-uracil-5-yl)-3-[6-phenyl-pyridazin-3(2H)-one-2-yl]-propanamide (346407-31-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 50 percent / K₂CO₃ / acetone / 24 h / Heating

2: aq. HCl

3: 70 percent / DCC / methanol / 24 h / 20 °C

With hydrogenchloride; potassium carbonate; dicyclohexyl-carbodiimide; In methanol; acetone;

DOI:10.1016/S0968-0896(00)00271-6

Reference yield:

ethyl 3-[6-phenyl-pyridazin-3(2H)-one-2-yl]-propionate (79222-83-6) → N1-(4-amino-3-methyl-1-propyl-uracil-5-yl)-3-[6-phenyl-pyridazin-3(2H)-one-2-yl]-propanamide (346407-31-6)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. HCl

2: 70 percent / DCC / methanol / 24 h / 20 °C

With hydrogenchloride; dicyclohexyl-carbodiimide; In methanol;

DOI:10.1016/S0968-0896(00)00271-6

upstream raw materials:

5,6-diamino-1-methyl-3-n-propyluracil

3-[6-phenyl-pyridazin-3(2H)-one-2-yl]-propanoic acid

6-phenylpyridazin-3(2H)-one

ethyl 3-[6-phenyl-pyridazin-3(2H)-one-2-yl]-propionate

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