4-amino-N-(2-chloro-6-fluoro-3-(N-(4-methoxybenzyl)(propylsulfonamido))phenyl)pyrido[3,2-d]pyrimidine-8-carboxamide

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Chemical Name:4-amino-N-(2-chloro-6-fluoro-3-(N-(4-methoxybenzyl)(propylsulfonamido))phenyl)pyrido[3,2-d]pyrimidine-8-carboxamide
CAS No.:1269421-88-6
Molecular Formula:C₂₅H₂₄ClFN₆O₄S
Molecular Weight:559.021
Hs Code.:

Synonyms:4-amino-N-(2-chloro-6-fluoro-3-(N-(4-methoxybenzyl)(propylsulfonamido))phenyl)pyrido[3,2-d]pyrimidine-8-carboxamide

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Chemical Property of 4-amino-N-(2-chloro-6-fluoro-3-(N-(4-methoxybenzyl)(propylsulfonamido))phenyl)pyrido[3,2-d]pyrimidine-8-carboxamide

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Technology Process of 4-amino-N-(2-chloro-6-fluoro-3-(N-(4-methoxybenzyl)(propylsulfonamido))phenyl)pyrido[3,2-d]pyrimidine-8-carboxamide

There total 7 articles about 4-amino-N-(2-chloro-6-fluoro-3-(N-(4-methoxybenzyl)(propylsulfonamido))phenyl)pyrido[3,2-d]pyrimidine-8-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1269421-87-5
N-(2-chloro-6-fluoro-3-(N-(4-methoxybenzyl)(propylsulfonamido))phenyl)-2-cyano-3-fluoroisonicotinamide

: 3473-63-0
formamidine acetic acid

: 1269421-88-6
4-amino-N-(2-chloro-6-fluoro-3-(N-(4-methoxybenzyl)(propylsulfonamido))phenyl)pyrido[3,2-d]pyrimidine-8-carboxamide

Guidance literature:: With N,N-dimethyl acetamide; at 160 ℃; for 0.5h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 628691-93-0
2-chloro-3-fluoro-pyridine-4-carboxylic acid

: 1269421-88-6
4-amino-N-(2-chloro-6-fluoro-3-(N-(4-methoxybenzyl)(propylsulfonamido))phenyl)pyrido[3,2-d]pyrimidine-8-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / 2 h / 80 °C

2: chloroform / 20 °C

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 0.33 h / 190 °C / Microwave irradiation; Inert atmosphere

4: N,N-dimethyl acetamide / 0.5 h / 160 °C / Inert atmosphere; Microwave irradiation

With thionyl chloride; N,N-dimethyl acetamide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In chloroform; N,N-dimethyl-formamide;

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 1269421-88-6
4-amino-N-(2-chloro-6-fluoro-3-(N-(4-methoxybenzyl)(propylsulfonamido))phenyl)pyrido[3,2-d]pyrimidine-8-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 3.75 h / 20 - 40 °C / Cooling with ice

1.2: 14.08 h / 0 - 20 °C

2.1: chloroform / 20 °C

3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 0.33 h / 190 °C / Microwave irradiation; Inert atmosphere

4.1: N,N-dimethyl acetamide / 0.5 h / 160 °C / Inert atmosphere; Microwave irradiation

With N,N-dimethyl acetamide; sodium hydride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In chloroform; N,N-dimethyl-formamide; mineral oil;