N-(2-chloro-6-fluoro-3-(N-(4-methoxybenzyl)(propylsulfonamido))phenyl)-2-cyano-3-fluoroisonicotinamide

Base Information

• Chemical Name: N-(2-chloro-6-fluoro-3-(N-(4-methoxybenzyl)(propylsulfonamido))phenyl)-2-cyano-3-fluoroisonicotinamide
• CAS No.: 1269421-87-5
• Molecular Formula: C₂₄H₂₁ClF₂N₄O₄S
• Molecular Weight: 534.971
• Mol file: 1269421-87-5.mol

Synonyms:N-(2-chloro-6-fluoro-3-(N-(4-methoxybenzyl)(propylsulfonamido))phenyl)-2-cyano-3-fluoroisonicotinamide

Chemical Property of N-(2-chloro-6-fluoro-3-(N-(4-methoxybenzyl)(propylsulfonamido))phenyl)-2-cyano-3-fluoroisonicotinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-chloro-6-fluoro-3-(N-(4-methoxybenzyl)(propylsulfonamido))phenyl)-2-cyano-3-fluoroisonicotinamide

There total 6 articles about N-(2-chloro-6-fluoro-3-(N-(4-methoxybenzyl)(propylsulfonamido))phenyl)-2-cyano-3-fluoroisonicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

zinc(II) cyanide (557-21-1) + 2-chloro-N-(2-chloro-6-fluoro-3-(N-(4-methoxybenzyl)(propylsulfonamido))phenyl)-3-fluoroisonicotinamide (1269421-86-4) → N-(2-chloro-6-fluoro-3-(N-(4-methoxybenzyl)(propylsulfonamido))phenyl)-2-cyano-3-fluoroisonicotinamide (1269421-87-5)

Guidance literature:

(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In N,N-dimethyl-formamide; at 190 ℃; for 0.333333h; Microwave irradiation; Inert atmosphere;

Reference yield:

2-chloro-3-fluoro-pyridine-4-carboxylic acid (628691-93-0) → N-(2-chloro-6-fluoro-3-(N-(4-methoxybenzyl)(propylsulfonamido))phenyl)-2-cyano-3-fluoroisonicotinamide (1269421-87-5)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / 2 h / 80 °C

2: chloroform / 20 °C

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 0.33 h / 190 °C / Microwave irradiation; Inert atmosphere

With thionyl chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In chloroform; N,N-dimethyl-formamide;

Reference yield:

p-methoxybenzyl chloride (824-94-2) → N-(2-chloro-6-fluoro-3-(N-(4-methoxybenzyl)(propylsulfonamido))phenyl)-2-cyano-3-fluoroisonicotinamide (1269421-87-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 3.75 h / 20 - 40 °C / Cooling with ice

1.2: 14.08 h / 0 - 20 °C

2.1: chloroform / 20 °C

3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 0.33 h / 190 °C / Microwave irradiation; Inert atmosphere

With sodium hydride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In chloroform; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

p-methoxybenzyl chloride

zinc(II) cyanide

2-chloro-N-(2-chloro-6-fluoro-3-(N-(4-methoxybenzyl)(propylsulfonamido))phenyl)-3-fluoroisonicotinamide

2-chloro-3-fluoro-pyridine-4-carboxylic acid

Downstream raw materials:

4-amino-N-(2-chloro-6-fluoro-3-(N-(4-methoxybenzyl)(propylsulfonamido))phenyl)pyrido[3,2-d]pyrimidine-8-carboxamide

4-amino-N-(2-chloro-6-fluoro-3-(propylsulfonamido)phenyl)-pyrido[3,2-d]pyrimidine-8-carboxamide